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研究甲基汞暴露下巨臀脂鲤红细胞中的微核和其他核异常。

Studies of micronuclei and other nuclear abnormalities in red blood cells of Colossoma macropomum exposed to methylmercury.

机构信息

Coordenação de Recursos Pesqueiros e Agronegócio, Instituto Federal de Educação, Ciência e Tecnologia do Pará, Belém, PA, Brazil.

出版信息

Genet Mol Biol. 2011 Oct;34(4):694-7. doi: 10.1590/S1415-47572011000400024. Epub 2011 Oct 1.

DOI:10.1590/S1415-47572011000400024
PMID:22215976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3229127/
Abstract

The frequencies of micronuclei (MN) and morphological nuclear abnormalities (NA) in erythrocytes in the peripheral blood of tambaqui (Colossoma macropomum), treated with 2 mg.L(-1) methylmercury (MeHg), were analyzed. Two groups (nine specimens in each) were exposed to MeHg for different periods (group A - 24 h; group B - 120 h). A third group served as negative control (group C, untreated; n = 9). Although, when compared to the control group there were no significant differences in MN frequency in the treated groups, for NA, the differences between the frequencies of group B (treated for 120 h) and the control group were extremely significant (p < 0.02), thus demonstrating the potentially adverse effects of MeHg on C. macropomum erythrocytes after prolonged exposure.

摘要

分析了用 2 毫克/升甲基汞(MeHg)处理过的淡水白鲳(Colossoma macropomum)外周血红细胞中的微核(MN)和形态核异常(NA)的频率。两组(每组 9 个标本)暴露于 MeHg 的时间不同(A 组-24 小时;B 组-120 小时)。第三组作为阴性对照(未处理的 C 组,n=9)。虽然与对照组相比,处理组的 MN 频率没有显著差异,但对于 NA,B 组(处理 120 小时)与对照组之间的差异极其显著(p<0.02),表明 MeHg 对淡水白鲳红细胞的潜在不利影响。经过长时间暴露。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aea/3229127/72f30a5ff2e3/gmb-34-1-694-gfig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aea/3229127/72f30a5ff2e3/gmb-34-1-694-gfig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aea/3229127/72f30a5ff2e3/gmb-34-1-694-gfig1.jpg

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