Instituto de Productos Naturales y Agrobiología (CSIC), Avenida Astrofísico F. Sánchez, 3, 38206 La Laguna, Tenerife, Spain.
J Nat Prod. 2012 Jan 27;75(1):115-8. doi: 10.1021/np200845f. Epub 2012 Jan 5.
Dactylomelatriol (1), obtained from the sea hare Aplysia dactylomela, is the first naturally occurring omphalane-derived sesquiterpene from the marine environment. From this species the known chamigrene and modified bisabolene sesquiterpenes 2-6 were also isolated. The structure and relative configuration of 1 were established by spectroscopic evidence. Its chemical structure is related to omphalic acid, the unique terrestrial-derived omphalane sesquiterpene isolated from a liverwort. A biogenetic route for this compound is proposed. The antimicrobial activities of compounds 1-6 were evaluated against a panel of microorganisms.
三亚姜烷型倍半萜 1 从海洋腹足纲软体动物 Aplysia dactylomela 中分离得到，是首个来源于海洋环境的天然 omphalane 衍生的倍半萜。从该物种中还分离到了已知的 chamigrene 和修饰的倍半萜 2-6。1 的结构和相对构型通过光谱证据确定。其化学结构与 omphalic acid 有关，omphalic acid 是从地钱中分离得到的唯一一种源自陆地的 omphalane 倍半萜。本文提出了该化合物的生物合成途径。对化合物 1-6 的抗微生物活性进行了评估，评估对象为一组微生物。
