Department of Medical Genetics, College of Medicine, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Rd., Kaohsiung 80708, Taiwan, ROC.
Food Chem Toxicol. 2012 Mar;50(3-4):779-89. doi: 10.1016/j.fct.2011.12.023. Epub 2011 Dec 23.
Toona sinensis Roem (T. sinensis) leaves have been used as a nutritious vegetable and been suggested for medical applications; however, the reported bioactive compounds of T. sinensis leaves are, so far, from high to mid-high polar extracts. Our aims in this study were to reveal the non-polar constituents of the T. sinensis leave extract that were prepared by a method of using a supercritical-CO2 fluid and to investigate the anti-diabetic potential of this extract. Through a GC/MS analysis, we revealed 24 major components of the non-polar T. sinensis leave extract, the most abundant of which was phytol. The non-polar T. sinensis leave extract showed to prevent the progression of diabetes and hepatosteatosis, the rise of triglycerol levels and the decrease of adiponectin levels in the type 2 diabetic mice. Our results suggest that the non-polar extract of T. sinensis leaves prepared using the supercritical-CO2 fluid may contain effective constituents to prevent type 2 diabetes.
香椿叶被用作营养丰富的蔬菜，并被推荐用于医疗应用；然而，迄今为止，香椿叶的报道生物活性化合物是从中等到高极性提取物。在这项研究中，我们的目的是揭示用超临界 CO2 流体制备的香椿叶提取物的非极性成分，并研究该提取物的抗糖尿病潜力。通过 GC/MS 分析，我们揭示了非极性香椿叶提取物的 24 种主要成分，其中最丰富的是植醇。非极性香椿叶提取物可预防 2 型糖尿病和肝脂肪变性、甘油三酯水平升高和脂联素水平降低。我们的结果表明，用超临界 CO2 流体制备的香椿叶非极性提取物可能含有有效成分，可预防 2 型糖尿病。
