Department of Anatomy and Cell Biology, Collage of Medicine, Hanyang University, Seoul 133-791, Republic of Korea.
Appetite. 2012 Apr;58(2):462-9. doi: 10.1016/j.appet.2011.12.015. Epub 2011 Dec 29.
Menopause is associated with an increased risk of cardiovascular disease (CVD). Exercise and soy isoflavone diets have been suggested to reduce the risk of CVD in postmenopausal women. We investigated the effects of exercise, or combined exercise and soy isoflavone diet, on plasma lipid profiles, paraoxonase (PON), nitric oxide (NO) and apoptosis in the aorta of ovariectomized (OVX) rats. Thirty-two female Sprague-Dawley rats were divided into four groups: OVX with general diet (OVX-GD), OVX with isoflavone diet (OVX-ISO), OVX-GD with exercise training (OVX-ET) and OVX-ISO with exercise training (OVX-ISO+ET). The experimental rats undertook treadmill training (30 min/day, 4 days/week) and/or were supplied a soy isoflavone diet (added to the experimental diet at 2.39 mg/g protein) for 12 weeks. Body weight and levels of total cholesterol (TC), triglyceride (TG), LDL-cholesterol (LDL-C) increased in the OVX rats and HDL-C decreased. These effects were reduced by exercise and/or soy isoflavone supplementation. PON and NO activities were higher in the OVX-ISO+ET group than in the OVX-GD group. In addition, this group had lower caspase-9 and -3 and higher Bcl-2 expression, and there was less aortic apoptotic cell death. These results suggest that a combination of exercise and a soy isoflavone diet has beneficial effects in terms of protecting against cardiovascular risk factors by controlling lipid profiles and the related enzyme, PON, as well as NO activity and apoptosis of the aorta in OVX rats.
绝经与心血管疾病（CVD）风险增加有关。运动和大豆异黄酮饮食已被建议降低绝经后妇女 CVD 的风险。我们研究了运动或运动与大豆异黄酮饮食联合对去卵巢（OVX）大鼠血浆脂质谱、对氧磷酶（PON）、一氧化氮（NO）和主动脉细胞凋亡的影响。32 只雌性 Sprague-Dawley 大鼠分为四组：普通饮食去卵巢组（OVX-GD）、大豆异黄酮饮食去卵巢组（OVX-ISO）、运动训练去卵巢组（OVX-ET）和运动训练与大豆异黄酮饮食联合去卵巢组（OVX-ISO+ET）。实验大鼠进行跑步机训练（30 分钟/天，每周 4 天）和/或接受大豆异黄酮饮食（添加到实验饮食中，蛋白含量为 2.39 毫克/克）12 周。OVX 大鼠的体重和总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）水平升高，HDL-C 降低。这些影响通过运动和/或大豆异黄酮补充得到了减轻。OVX-ISO+ET 组的 PON 和 NO 活性高于 OVX-GD 组。此外，该组的 caspase-9 和 -3 表达较低，Bcl-2 表达较高，主动脉细胞凋亡减少。这些结果表明，运动和大豆异黄酮饮食的联合使用通过控制脂质谱和相关酶 PON 以及 NO 活性和 OVX 大鼠主动脉细胞凋亡，对心血管危险因素具有有益的保护作用。
