Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, San Diego, CA, 92093, USA.
AIDS Behav. 2012 Nov;16(8):2309-18. doi: 10.1007/s10461-011-0121-x.
HIV infection and older age are each independently associated with lower health-related quality of life (HRQoL) and deficits in prospective memory (PM), which is a distinct aspect of cognition involving the ability to "remember to remember" to do something at a future occasion. The present study investigated associations between PM and HRQoL in 72 older (≥ 50 years) and 41 younger (≤ 40 years) HIV-infected adults. Self-reported PM complaints predicted HRQoL across the entire sample, but there was a significant interaction between performance-based PM and age group on HRQoL, such that lower time-based PM was associated with lower HRQoL only in the younger cohort. Within the younger group, time-based and self-reported PM significantly predicted mental HRQoL independent of other risk factors (e.g. depression). These findings suggest that PM plays a unique role in HRQoL outcomes among younger persons living with HIV infection and support the examination of other age-related factors (e.g. effective use of compensatory strategies) that may regulate the adverse impact of PM on everyday functioning.
HIV 感染和年龄增长均与健康相关生活质量（HRQoL）降低和前瞻性记忆（PM）缺陷独立相关，PM 是认知的一个独特方面，涉及在未来某个场合“记得要记得”做某事的能力。本研究调查了 72 名老年（≥50 岁）和 41 名年轻（≤40 岁）HIV 感染成年人之间 PM 和 HRQoL 之间的关联。自我报告的 PM 抱怨预测了整个样本的 HRQoL，但基于表现的 PM 和年龄组之间存在 HRQoL 的显著交互作用，即仅在年轻队列中，基于时间的 PM 较低与 HRQoL 较低相关。在年轻组中，基于时间和自我报告的 PM 独立于其他风险因素（例如抑郁）显著预测心理 HRQoL。这些发现表明，PM 在年轻的 HIV 感染者的 HRQoL 结果中起着独特的作用，并支持对其他与年龄相关的因素（例如有效使用补偿策略）进行检查，这些因素可能会调节 PM 对日常功能的不利影响。
