Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain.
Inflamm Res. 2012 May;61(5):427-35. doi: 10.1007/s00011-011-0429-z. Epub 2012 Jan 19.
This cross-sectional study assessed the potential contribution of gender, body fat distribution, and their interactions to some inflammatory marker concentrations [C-reactive protein (CRP), complement factor 3 (C3), and ceruloplasmin (Cp)] in young adults.
Measurements included body composition, lifestyle features, blood biochemical and selected inflammatory markers on 317 healthy subjects [122 males/195 females; 22 ± 3 years; 22.1 ± 2.8 kg/m(2) (mean ± SD)].
Women had significantly higher CRP and Cp concentrations than men. No gender difference was noted in C3 concentrations. In a multivariate model of the whole sample, body fat (BF), waist circumference (WC) and the sex × WC interaction term presented the highest R (2) for variance of CRP (11%), C3 (2%), and Cp (12%), respectively. In regression models separated by sex, BF was the adiposity indicator that explained the variability of CRP in men (13%) and women (7%). WC was the only variable significantly associated with C3 concentrations in women (3%). BF presented the highest partial R (2) for Cp in men (8%) and WC in women (16%).
Our findings indicate a relevant interaction between gender and body fat distribution on the variance of CRP, C3, and Cp concentrations in apparently healthy young adults.
本横断面研究评估了性别、体脂分布及其相互作用对一些炎症标志物浓度（C 反应蛋白（CRP）、补体因子 3（C3）和铜蓝蛋白（Cp））的潜在影响，这些标志物存在于年轻成年人中。
研究纳入了 317 名健康受试者（122 名男性/195 名女性；年龄 22±3 岁；体重指数 22.1±2.8（均值±标准差）），对其进行了身体成分、生活方式特征、血液生化和部分炎症标志物的检测。
女性 CRP 和 Cp 浓度显著高于男性。C3 浓度在性别间无差异。在整个样本的多元模型中，体脂肪（BF）、腰围（WC）和性别与 WC 的交互项分别对 CRP（11%）、C3（2%）和 Cp（12%）的变异有最高的 R²。在按性别分开的回归模型中，BF 是解释男性（13%）和女性（7%）CRP 变异的肥胖指标。WC 是唯一与女性 C3 浓度显著相关的变量（3%）。BF 对男性 Cp 的部分 R²最高（8%），WC 对女性 Cp 的部分 R²最高（16%）。
我们的研究结果表明，在表型健康的年轻成年人中，性别和体脂分布之间存在显著的相互作用，这对 CRP、C3 和 Cp 浓度的变异性有影响。
