Section of Neurobiology of Psychosis, Department of Psychosis Studies, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK.
Schizophr Res. 2012 Mar;135(1-3):23-7. doi: 10.1016/j.schres.2011.12.024. Epub 2012 Jan 20.
Altered neuroplasticity is increasingly invoked as a mechanism underpinning dysconnectivity in schizophrenia. We used Dynamic Causal Modelling to compare connectivity during the magnetic auditory Mismatch Negativity (MMN), an index of error prediction, between schizophrenia patients and controls. Patients showed reduced intrinsic connectivity within the primary auditory cortex suggestive of impaired local neuronal adaptation and disrupted forward and backward extrinsic connectivity throughout the MMN network indicative of reduced higher order input in disambiguating activity in lower network nodes. Our study provides the first empirical description of the dysplastic changes underpinning dysconnectivity between primary sensory and higher order cortical areas in schizophrenia.
神经可塑性的改变越来越被认为是精神分裂症中连接中断的基础机制。我们使用动态因果建模来比较精神分裂症患者和对照组在磁听觉失匹配负波（MMN）期间的连接，MMN 是错误预测的指标。患者表现出初级听觉皮层内内在连接的减少，表明局部神经元适应受损，以及在整个 MMN 网络中向前和向后外在连接的破坏，表明在较低网络节点的活动中，用于区分的高级别输入减少。我们的研究首次提供了精神分裂症中初级感觉和高级皮质区域之间连接中断的基础神经可塑性变化的经验描述。
