氨苄青霉素功能化纳米颗粒可消灭多重耐药铜绿假单胞菌和产气肠杆菌以及耐甲氧西林金黄色葡萄球菌的分离株。
Nanoparticles functionalized with ampicillin destroy multiple-antibiotic-resistant isolates of Pseudomonas aeruginosa and Enterobacter aerogenes and methicillin-resistant Staphylococcus aureus.
机构信息
Department of Biological Sciences, Western Michigan University, Kalamazoo, Michigan, USA.
出版信息
Appl Environ Microbiol. 2012 Apr;78(8):2768-74. doi: 10.1128/AEM.06513-11. Epub 2012 Jan 27.
Abstract
We show here that silver nanoparticles (AgNP) were intrinsically antibacterial, whereas gold nanoparticles (AuNP) were antimicrobial only when ampicillin was bound to their surfaces. Both AuNP and AgNP functionalized with ampicillin were effective broad-spectrum bactericides against Gram-negative and Gram-positive bacteria. Most importantly, when AuNP and AgNP were functionalized with ampicillin they became potent bactericidal agents with unique properties that subverted antibiotic resistance mechanisms of multiple-drug-resistant bacteria.
摘要
我们在此表明，银纳米颗粒（AgNP）具有内在的抗菌性，而金纳米颗粒（AuNP）只有在氨苄青霉素结合到其表面时才具有抗菌性。氨苄青霉素功能化的 AuNP 和 AgNP 均对革兰氏阴性菌和革兰氏阳性菌有效，具有广谱杀菌作用。最重要的是，当 AuNP 和 AgNP 用氨苄青霉素功能化后，它们成为具有独特性质的杀菌剂，可以颠覆多种耐药细菌的抗生素耐药机制。
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