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本文引用的文献

1
New antibacterial therapeutics and strategies.新型抗菌治疗方法与策略。
Pol J Microbiol. 2011;60(1):3-12.
2
Surface-enhanced Raman imaging of intracellular bioreduction of chromate in Shewanella oneidensis.利用 Shewanella oneidensis 细胞内生物还原作用的表面增强拉曼成像对铬酸盐进行检测。
PLoS One. 2011 Feb 25;6(2):e16634. doi: 10.1371/journal.pone.0016634.
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Challenges of antibacterial discovery.抗菌药物发现的挑战。
Clin Microbiol Rev. 2011 Jan;24(1):71-109. doi: 10.1128/CMR.00030-10.
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Gold nanostructures: a class of multifunctional materials for biomedical applications.金纳米结构：一类用于生物医学应用的多功能材料。
Chem Soc Rev. 2011 Jan;40(1):44-56. doi: 10.1039/b821763g. Epub 2010 Sep 6.
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The bactericidal effect of silver nanoparticles.银纳米颗粒的杀菌作用。
Nanotechnology. 2005 Oct;16(10):2346-53. doi: 10.1088/0957-4484/16/10/059. Epub 2005 Aug 26.
6
Silver nanoparticles-modified films versus biomedical device-associated infections.载银纳米粒子修饰膜与生物医学器械相关性感染
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 Nov-Dec;2(6):670-84. doi: 10.1002/wnan.113.
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Nanosilver as a new generation of nanoproduct in biomedical applications.纳米银作为新一代纳米产品在生物医学中的应用。
Trends Biotechnol. 2010 Nov;28(11):580-8. doi: 10.1016/j.tibtech.2010.07.006. Epub 2010 Aug 18.
8
Glucosamine-functionalized silver glyconanoparticles: characterization and antibacterial activity.葡萄糖胺功能化银糖纳米颗粒的表征及抗菌活性。
Anal Bioanal Chem. 2010 Sep;398(2):867-76. doi: 10.1007/s00216-010-3964-5. Epub 2010 Jul 11.
9
On the Enhanced Antibacterial Activity of Antibiotics Mixed with Gold Nanoparticles.关于抗生素与金纳米颗粒混合后的增强抗菌活性
Nanoscale Res Lett. 2009 Apr 21;4(8):794-801. doi: 10.1007/s11671-009-9316-8.
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The synthesis of chitosan-based silver nanoparticles and their antibacterial activity.壳聚糖基银纳米粒子的合成及其抗菌活性。
Carbohydr Res. 2009 Nov 23;344(17):2375-82. doi: 10.1016/j.carres.2009.09.001. Epub 2009 Sep 4.

氨苄青霉素功能化纳米颗粒可消灭多重耐药铜绿假单胞菌和产气肠杆菌以及耐甲氧西林金黄色葡萄球菌的分离株。

Nanoparticles functionalized with ampicillin destroy multiple-antibiotic-resistant isolates of Pseudomonas aeruginosa and Enterobacter aerogenes and methicillin-resistant Staphylococcus aureus.

机构信息

Department of Biological Sciences, Western Michigan University, Kalamazoo, Michigan, USA.

出版信息

Appl Environ Microbiol. 2012 Apr;78(8):2768-74. doi: 10.1128/AEM.06513-11. Epub 2012 Jan 27.

DOI:10.1128/AEM.06513-11
PMID:22286985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3318834/
Abstract

We show here that silver nanoparticles (AgNP) were intrinsically antibacterial, whereas gold nanoparticles (AuNP) were antimicrobial only when ampicillin was bound to their surfaces. Both AuNP and AgNP functionalized with ampicillin were effective broad-spectrum bactericides against Gram-negative and Gram-positive bacteria. Most importantly, when AuNP and AgNP were functionalized with ampicillin they became potent bactericidal agents with unique properties that subverted antibiotic resistance mechanisms of multiple-drug-resistant bacteria.

摘要

我们在此表明，银纳米颗粒（AgNP）具有内在的抗菌性，而金纳米颗粒（AuNP）只有在氨苄青霉素结合到其表面时才具有抗菌性。氨苄青霉素功能化的 AuNP 和 AgNP 均对革兰氏阴性菌和革兰氏阳性菌有效，具有广谱杀菌作用。最重要的是，当 AuNP 和 AgNP 用氨苄青霉素功能化后，它们成为具有独特性质的杀菌剂，可以颠覆多种耐药细菌的抗生素耐药机制。