一个解决 2-吡啶问题的通用方法。
A general solution for the 2-pyridyl problem.
机构信息
Howard Hughes Medical Institute, Department of Chemistry, University of Illinois at Urbana-Champaign, 61801, USA.
出版信息
Angew Chem Int Ed Engl. 2012 Mar 12;51(11):2667-72. doi: 10.1002/anie.201108608. Epub 2012 Jan 27.
Problem solved: an air-stable 2-pyridyl borane that can effectively couple to a wide range of aryl and heteroaryl halides and pseudohalides has evaded the synthesis community for decades. The discovery that Cu(DEA)(2) powerfully enables palladium-mediated cross-couplings with air-stable boronates 1 has finally provided a general solution to this problem. DEA=diethanolamine, DMF=N,N'-dimethylformamide, Tf=trifluoromethanesulfonyl.
问题解决了
一种稳定的 2-吡啶基硼烷，能够有效地与各种芳基和杂芳基卤化物和拟卤化物偶联，几十年来一直困扰着合成界。人们发现，Cu(DEA)(2) 能够有力地促进钯介导的与稳定的硼酸盐 1 的交叉偶联，这终于为这个问题提供了一个通用的解决方案。DEA=二乙醇胺，DMF=N，N'-二甲基甲酰胺，Tf=三氟甲磺酸。
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