Department of Biomedical Engineering, Cornell University, Ithaca, New York, USA.
Magn Reson Med. 2012 Nov;68(5):1579-85. doi: 10.1002/mrm.24151. Epub 2012 Jan 31.
Fast methods using balanced steady-state free precession have been developed to reduce the scan time of T₁ and T₂ mapping. However, flip angle (FA) profiles created by the short radiofrequency pulses used in steady-state free precession deviate substantially from the ideal rectangular profile, causing T₁ and T₂ mapping errors. The purpose of this study was to develop a FA profile correction for T₁ and T₂ mapping with Look-Locker 2D inversion recovery steady-state free precession and to validate this method using 2D spin echo as a reference standard. Phantom studies showed consistent improvement in T₁ and T₂ accuracy using profile correction at multiple FAs. Over six human calves, profile correction provided muscle T₁ estimates with mean error ranging from excellent (-0.6%) at repetition time/FA = 18 ms/60° to acceptable (6.8%) at repetition time/FA = 4.9 ms/30°, while muscle T₂ estimates were less accurate with mean errors of 31.2% and 47.9%, respectively.
快速方法使用平衡稳态自由进动来减少 T₁ 和 T₂ 映射的扫描时间。然而,稳态自由进动中使用的短射频脉冲产生的翻转角(FA)曲线与理想的矩形曲线有很大的偏差,导致 T₁ 和 T₂ 映射误差。本研究的目的是开发一种用于 T₁ 和 T₂ 映射的 FA 曲线校正方法,使用 Look-Locker 2D 反转恢复稳态自由进动,并使用 2D 自旋回波作为参考标准对该方法进行验证。在多个 FA 下进行的体模研究表明,使用曲线校正可显著提高 T₁ 和 T₂ 的准确性。在六例人类小腿中,在重复时间/FA = 18 ms/60°时,曲线校正可提供平均误差范围从优秀(-0.6%)到可接受(6.8%)的肌肉 T₁ 估计,而在重复时间/FA = 4.9 ms/30°时,肌肉 T₂ 估计则不太准确,平均误差分别为 31.2%和 47.9%。