利用进化生物学来对抗传染病。
Harnessing evolutionary biology to combat infectious disease.
机构信息
Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
出版信息
Nat Med. 2012 Feb 6;18(2):217-20. doi: 10.1038/nm.2572.
Abstract
Pathogens exhibit remarkable abilities to flout therapeutic intervention. This outcome is driven by evolution, either as a direct response to intervention (e.g. the evolution of antibiotic resistance), or through long-term coevolution generating host or parasite traits that interact with therapy in undesirable or unpredicted ways. To make progress, the concepts and techniques of evolutionary biology must be deeply integrated with traditional approaches to immunology and pathogen biology. An interdisciplinary approach can inform control strategies, or even patient treatment, positioning us to meet the current and future challenges of controlling infectious diseases.
摘要
病原体表现出了显著的逃避治疗干预的能力。这种结果是由进化驱动的，或者是作为对干预的直接反应（例如抗生素耐药性的进化），或者是通过长期的共同进化产生宿主或寄生虫特征，以不理想或不可预测的方式与治疗相互作用。为了取得进展，必须将进化生物学的概念和技术与传统的免疫学和病原体生物学方法深入结合。跨学科方法可以为控制策略提供信息，甚至可以为患者治疗提供信息，使我们能够应对当前和未来控制传染病的挑战。
相似文献
1
Harnessing evolutionary biology to combat infectious disease.利用进化生物学来对抗传染病。
Nat Med. 2012 Feb 6;18(2):217-20. doi: 10.1038/nm.2572.
2
Message from the Editor-in-Chief.主编寄语。
Anaerobe. 2015 Feb;31:1. doi: 10.1016/j.anaerobe.2014.11.010. Epub 2014 Nov 20.
3
Potential Relevance of Melatonin Against Some Infectious Agents: A Review and Assessment of Recent Research.褪黑素对某些感染因子的潜在相关性：近期研究综述与评估
Curr Med Chem. 2015;22(33):3848-61. doi: 10.2174/0929867322666150827093730.
4
Antisense antimicrobial therapeutics.反义抗菌疗法
Curr Opin Microbiol. 2016 Oct;33:47-55. doi: 10.1016/j.mib.2016.05.017. Epub 2016 Jun 29.
5
The ecology of genetically diverse infections.基因多样化感染的生态学
Science. 2001 May 11;292(5519):1099-102. doi: 10.1126/science.1059410.
6
Evolutionary biology. Parasites and polymorphisms.进化生物学。寄生虫与多态性。
Nature. 1994 Jun 30;369(6483):705-6. doi: 10.1038/369705a0.
7
A review of bacterial resistance to antimicrobial agents in tropical countries.热带国家细菌对抗菌药物的耐药性综述。
Ann Trop Paediatr. 1993;13(3):219-26. doi: 10.1080/02724936.1993.11747649.
8
Confronting parasites from Canada.应对来自加拿大的寄生虫。
Trends Parasitol. 2002 Dec;18(12):519-21. doi: 10.1016/s1471-4922(02)02369-3.
9
Hybridization in Parasites: Consequences for Adaptive Evolution, Pathogenesis, and Public Health in a Changing World.寄生虫中的杂交：在不断变化的世界中对适应性进化、发病机制和公共卫生的影响
PLoS Pathog. 2015 Sep 3;11(9):e1005098. doi: 10.1371/journal.ppat.1005098. eCollection 2015 Sep.
10
Antifolate resistance mechanisms from bacteria to cancer cells with emphasis on parasites.
Adv Exp Med Biol. 1998;456:99-113. doi: 10.1007/978-1-4615-4897-3_6.
引用本文的文献
1
Molecular Evolution and Phylogeography of the Crimean-Congo Hemorrhagic Fever Virus.克里米亚-刚果出血热病毒的分子进化与系统地理学
Viruses. 2025 Jul 28;17(8):1054. doi: 10.3390/v17081054.
2
Subdominance in Antibody Responses: Implications for Vaccine Development.抗体反应中的次优势性：对疫苗开发的影响。
Microbiol Mol Biol Rev. 2020 Nov 25;85(1). doi: 10.1128/MMBR.00078-20.
3
Synthesis of glycopolymers with specificity for bacterial strains bacteria-guided polymerization.具有对细菌菌株特异性的糖聚合物的合成——细菌引导聚合
Chem Sci. 2019 Apr 18;10(20):5251-5257. doi: 10.1039/c8sc05561k. eCollection 2019 May 28.
4
Vector Immunity and Evolutionary Ecology: The Harmonious Dissonance.向量免疫与进化生态学：和谐的不和谐。
Trends Immunol. 2018 Nov;39(11):862-873. doi: 10.1016/j.it.2018.09.003. Epub 2018 Oct 6.
5
Polymers for binding of the gram-positive oral pathogen Streptococcus mutans.用于结合革兰氏阳性口腔病原体变形链球菌的聚合物。
PLoS One. 2017 Jul 3;12(7):e0180087. doi: 10.1371/journal.pone.0180087. eCollection 2017.
6
A Syst-OMICS Approach to Ensuring Food Safety and Reducing the Economic Burden of Salmonellosis.一种确保食品安全并减轻沙门氏菌病经济负担的系统组学方法。
Front Microbiol. 2017 Jun 2;8:996. doi: 10.3389/fmicb.2017.00996. eCollection 2017.
7
Genomics of antibiotic-resistance prediction in Pseudomonas aeruginosa.铜绿假单胞菌抗生素耐药性预测的基因组学。
Ann N Y Acad Sci. 2019 Jan;1435(1):5-17. doi: 10.1111/nyas.13358. Epub 2017 Jun 2.
8
Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium.国际铜绿假单胞菌联盟所产生的基因组学数据的临床应用。
Front Microbiol. 2015 Sep 29;6:1036. doi: 10.3389/fmicb.2015.01036. eCollection 2015.
9
Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling.细菌指导的聚合物合成用于自我选择的微生物结合和标记。
Nat Mater. 2014 Jul;13(7):748-55. doi: 10.1038/nmat3949. Epub 2014 May 11.
10
The gain of hydrogen peroxide resistance benefits growth fitness in mycobacteria under stress.过氧化氢抗性的增强有利于分枝杆菌在应激状态下的生长适应性。
Protein Cell. 2014 Mar;5(3):182-5. doi: 10.1007/s13238-014-0024-5.
本文引用的文献
1
Protective efficacy of serially up-ranked subdominant CD8+ T cell epitopes against virus challenges.针对病毒挑战的连续上调亚优势 CD8+ T 细胞表位的保护效力。
PLoS Pathog. 2011 May;7(5):e1002041. doi: 10.1371/journal.ppat.1002041. Epub 2011 May 19.
2
Host-mediated regulation of superinfection in malaria.宿主介导的疟疾再感染调控。
Nat Med. 2011 Jun;17(6):732-7. doi: 10.1038/nm.2368. Epub 2011 May 15.
3
Sickle hemoglobin confers tolerance to Plasmodium infection.镰状血红蛋白使机体对疟原虫感染具有耐受性。
Cell. 2011 Apr 29;145(3):398-409. doi: 10.1016/j.cell.2011.03.049.
4
A plethora of Plasmodium species in wild apes: a source of human infection?野生猿类中存在大量疟原虫物种：人类感染的源头？
Trends Parasitol. 2011 May;27(5):222-9. doi: 10.1016/j.pt.2011.01.006. Epub 2011 Feb 25.
5
Wild immunology.野生免疫学
Mol Ecol. 2011 Mar;20(5):872-80. doi: 10.1111/j.1365-294X.2010.04938.x. Epub 2011 Jan 3.
6
Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression.拉沙病毒核蛋白结构揭示了一种 dsRNA 特异性 3' 到 5' 外切酶活性，对于免疫抑制至关重要。
Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2396-401. doi: 10.1073/pnas.1016404108. Epub 2011 Jan 24.
7
How can vaccines against influenza and other viral diseases be made more effective?如何提高流感疫苗及其他病毒性疾病疫苗的效力？
PLoS Biol. 2010 Dec 21;8(12):e1000571. doi: 10.1371/journal.pbio.1000571.
8
Fitness correlates of heritable variation in antibody responsiveness in a wild mammal.野生哺乳动物抗体反应遗传变异的适应性相关性。
Science. 2010 Oct 29;330(6004):662-5. doi: 10.1126/science.1194878.
9
Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy.丝虫寄生虫在应对决定丝虫寿命的宿主免疫效应物时，发育得更快，繁殖得更早。
PLoS Biol. 2010 Oct 19;8(10):e1000525. doi: 10.1371/journal.pbio.1000525.
10
Species interactions in a parasite community drive infection risk in a wildlife population.寄生虫群落中的物种相互作用会影响野生动物种群的感染风险。
Science. 2010 Oct 8;330(6001):243-6. doi: 10.1126/science.1190333.
Zotero 插件