Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
Nat Med. 2012 Feb 6;18(2):217-20. doi: 10.1038/nm.2572.
Pathogens exhibit remarkable abilities to flout therapeutic intervention. This outcome is driven by evolution, either as a direct response to intervention (e.g. the evolution of antibiotic resistance), or through long-term coevolution generating host or parasite traits that interact with therapy in undesirable or unpredicted ways. To make progress, the concepts and techniques of evolutionary biology must be deeply integrated with traditional approaches to immunology and pathogen biology. An interdisciplinary approach can inform control strategies, or even patient treatment, positioning us to meet the current and future challenges of controlling infectious diseases.
病原体表现出了显著的逃避治疗干预的能力。这种结果是由进化驱动的，或者是作为对干预的直接反应（例如抗生素耐药性的进化），或者是通过长期的共同进化产生宿主或寄生虫特征，以不理想或不可预测的方式与治疗相互作用。为了取得进展，必须将进化生物学的概念和技术与传统的免疫学和病原体生物学方法深入结合。跨学科方法可以为控制策略提供信息，甚至可以为患者治疗提供信息，使我们能够应对当前和未来控制传染病的挑战。
