追求同源物的社区标准。
Toward community standards in the quest for orthologs.
出版信息
Bioinformatics. 2012 Mar 15;28(6):900-4. doi: 10.1093/bioinformatics/bts050. Epub 2012 Feb 12.
Abstract
The identification of orthologs-genes pairs descended from a common ancestor through speciation, rather than duplication-has emerged as an essential component of many bioinformatics applications, ranging from the annotation of new genomes to experimental target prioritization. Yet, the development and application of orthology inference methods is hampered by the lack of consensus on source proteomes, file formats and benchmarks. The second 'Quest for Orthologs' meeting brought together stakeholders from various communities to address these challenges. We report on achievements and outcomes of this meeting, focusing on topics of particular relevance to the research community at large. The Quest for Orthologs consortium is an open community that welcomes contributions from all researchers interested in orthology research and applications.
摘要
通过物种形成，从共同祖先传承下来的直系同源基因对的鉴定，而不是通过复制，已经成为许多生物信息学应用的重要组成部分，从新基因组的注释到实验目标的优先级排序。然而，直系同源推断方法的开发和应用受到缺乏共识的源蛋白质组、文件格式和基准的阻碍。第二次“寻找直系同源物”会议汇集了来自不同领域的利益相关者，以解决这些挑战。我们报告了这次会议的成果和结果，重点关注对广大研究界特别相关的主题。寻找直系同源物联盟是一个开放的社区，欢迎所有对直系同源研究和应用感兴趣的研究人员做出贡献。
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