Blanchard-Rohner Geraldine, Meier Sara, Ryser Joelle, Schaller Diane, Combescure Christophe, Yudin Mark H, Burton-Jeangros Claudine, de Tejada Begoña Martinez, Siegrist Claire-Anne
Department of Paediatrics, Children's Hospital of Geneva, Geneva, Switzerland.
J Matern Fetal Neonatal Med. 2012 Sep;25(9):1800-9. doi: 10.3109/14767058.2012.663835. Epub 2012 Mar 16.
Pregnant women and infants are at increased risk of vaccine-preventable complications due to influenza. In Switzerland, immunization was first recommended to all pregnant women in 2009. We assessed the acceptability of this recommendation and its determinants two seasons later.
Women having delivered in the University Hospitals of Geneva during March 2011 were asked to fill in a questionnaire assessing their knowledge, beliefs and acceptability of influenza vaccination during pregnancy.
The questionnaire was completed by 261/323 (80%) women. Out of 261, 213 (82%) were aware of increased risks of influenza during pregnancy, and 119/261 (46%) knew that immunization was recommended during pregnancy. Only 110/261 (42%) recalled an immunization advise during their pregnancy and only 47/261 (18%) had been immunized. A direct recommendation was the main predictor of immunization, associated with a 107-fold increased likelihood of vaccination. Factors identified by multivariate analyses as independently associated with the likelihood of immunization were to have been recommended immunization by a private (OR 9.1) or hospital (OR 4.7) obstetrician rather than a midwife, to have no fear that immunization could cause preterm delivery (OR 0.3) and to have been immunized in previous years (OR 10.7).
Two years after the recommendation of influenza immunization during pregnancy, most post-partum women recalled being neither recommended nor adequately informed about influenza vaccine and its safety. This identifies major gaps in awareness and/or communication in healthcare workers and suggests that improving immunization safety/efficacy awareness among obstetricians as the most likely method to improve flu immunization during pregnancy.
孕妇和婴儿因流感而发生疫苗可预防并发症的风险增加。在瑞士，2009年首次建议所有孕妇接种流感疫苗。两季过后，我们评估了这一建议的可接受性及其决定因素。
要求2011年3月在日内瓦大学医院分娩的妇女填写一份问卷，评估她们对孕期流感疫苗接种的知识、信念和可接受性。
261/323名（80%）妇女完成了问卷。在261名妇女中，213名（82%）知道孕期流感风险增加，119/261名（46%）知道孕期建议接种疫苗。只有110/261名（42%）回忆起孕期有过接种建议，只有47/261名（18%）接种过疫苗。直接建议是接种疫苗的主要预测因素，与接种可能性增加107倍相关。多变量分析确定的与接种可能性独立相关的因素包括，由私人（比值比9.1）或医院（比值比4.7）产科医生而非助产士建议接种，不担心接种会导致早产（比值比0.3），以及前几年接种过（比值比10.7）。
在建议孕期接种流感疫苗两年后，大多数产后妇女回忆说既没有得到接种建议，也没有充分了解流感疫苗及其安全性。这表明医护人员在认识和/或沟通方面存在重大差距，并建议提高产科医生对疫苗接种安全性/有效性的认识，这是提高孕期流感疫苗接种率最有可能的方法。
