Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA.
Circ Res. 2012 Feb 17;110(4):638-50. doi: 10.1161/CIRCRESAHA.111.247437.
Disturbances in gene expression as a result of perturbed transcription or posttranscriptional regulation is one of the main causes of cellular dysfunction that underlies different disease states. Approximately a decade ago, the discovery of microRNAs in mammalian cells has renewed our focus on posttranscriptional regulatory mechanisms during pathogenesis. These tiny posttranscriptional regulators are differentially expressed in almost every disease that has been studied to date and can modulate expression of a gene via specifically binding to its messenger RNA. Because of their capacity to simultaneously target multiple functionally related, genes, they are proving to be potentially powerful therapeutic agents/targets. In this review, we focus on the microRNAs that are differentially regulated in the more common cardiovascular pathologies, their targets, and potential function.
由于转录或转录后调节受到干扰，导致基因表达紊乱，是导致不同疾病状态下细胞功能障碍的主要原因之一。大约十年前，在哺乳动物细胞中发现 microRNAs，这重新引起了我们对发病机制过程中转录后调控机制的关注。这些微小的转录后调控因子在迄今为止研究过的几乎每种疾病中都有差异表达，并且可以通过特异性结合其信使 RNA 来调节基因的表达。由于它们能够同时针对多个功能相关的基因，因此它们被证明是具有潜在治疗作用的药物/靶点。在这篇综述中，我们重点关注在更常见的心血管病理中差异调节的 microRNAs、它们的靶标以及潜在功能。
