一种具有红色荧光发射的萤火虫 D-荧光素的硒类似物。
A selenium analogue of firefly D-luciferin with red-shifted bioluminescence emission.
机构信息
Department of Chemistry, Stanford University, CA 94305-5080, USA.
出版信息
Angew Chem Int Ed Engl. 2012 Apr 2;51(14):3350-3. doi: 10.1002/anie.201105653. Epub 2012 Feb 17.
Abstract
A selenium analogue of amino-D-luciferin, aminoseleno-D-luciferin, is synthesized and shown to be a competent substrate for the firefly luciferase enzyme. It has a red-shifted bioluminescence emission maximum at 600 nm and is suitable for bioluminescence imaging studies in living subjects.
摘要
合成了一种氨基-D-荧光素的硒类似物，即氨基硒代-D-荧光素，并证明它是萤火虫荧光素酶的一种有活性的底物。它的生物发光发射最大值在 600nm 处红移，适合在活体研究中进行生物发光成像研究。
相似文献
1
A selenium analogue of firefly D-luciferin with red-shifted bioluminescence emission.一种具有红色荧光发射的萤火虫 D-荧光素的硒类似物。
Angew Chem Int Ed Engl. 2012 Apr 2;51(14):3350-3. doi: 10.1002/anie.201105653. Epub 2012 Feb 17.
2
Robust light emission from cyclic alkylaminoluciferin substrates for firefly luciferase.环状烷基氨荧光素底物的萤火虫荧光素酶的强发光。
J Am Chem Soc. 2010 Oct 6;132(39):13586-7. doi: 10.1021/ja104525m.
3
Brominated Luciferins Are Versatile Bioluminescent Probes.溴化虫荧光素是多功能生物发光探针。
Chembiochem. 2017 Jan 3;18(1):96-100. doi: 10.1002/cbic.201600564. Epub 2016 Dec 8.
4
Evaluating Brightness and Spectral Properties of Click Beetle and Firefly Luciferases Using Luciferin Analogues: Identification of Preferred Pairings of Luciferase and Substrate for In Vivo Bioluminescence Imaging.利用荧光素类似物评估叩头虫和萤火虫荧光素酶的亮度和光谱特性：用于体内生物发光成像的荧光素酶和底物的优选配对物的鉴定。
Mol Imaging Biol. 2020 Dec;22(6):1523-1531. doi: 10.1007/s11307-020-01523-7. Epub 2020 Sep 14.
5
Design and Synthesis of an Alkynyl Luciferin Analogue for Bioluminescence Imaging.用于生物发光成像的炔基虫荧光素类似物的设计与合成
Chemistry. 2016 Mar 7;22(11):3671-5. doi: 10.1002/chem.201503944. Epub 2016 Jan 19.
6
A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging.一种产生近红外生物发光的荧光素类似物可实现高灵敏度的深层组织成像。
Nat Commun. 2016 Jun 14;7:11856. doi: 10.1038/ncomms11856.
7
An allylated firefly luciferin analogue with luciferase specific response in living cells.一种在活细胞中具有荧光素酶特异性响应的烯丙基化萤火虫荧光素类似物。
Chem Commun (Camb). 2018 Feb 13;54(14):1774-1777. doi: 10.1039/c7cc09720d.
8
How to Select Firefly Luciferin Analogues for In Vivo Imaging.如何为活体成像选择萤火虫荧光素类似物。
Int J Mol Sci. 2021 Feb 12;22(4):1848. doi: 10.3390/ijms22041848.
9
Photoactivable bioluminescent probes for imaging luciferase activity.用于成像荧光素酶活性的光激活生物发光探针。
Chem Commun (Camb). 2009 Jul 21(27):4028-30. doi: 10.1039/b908346d. Epub 2009 Jun 9.
10
Rational design and development of near-infrared-emitting firefly luciferins available in vivo.体内可用的近红外发光萤火虫荧光素的合理设计与开发。
Angew Chem Int Ed Engl. 2013 Jan 21;52(4):1175-9. doi: 10.1002/anie.201205151. Epub 2012 Dec 4.
引用本文的文献
1
PEGylated ATP-Independent Luciferins for Noninvasive High-Sensitivity High-Speed Bioluminescence Imaging.用于非侵入性高灵敏度高速生物发光成像的聚乙二醇化非ATP依赖型荧光素
ACS Chem Biol. 2025 Jan 17;20(1):128-136. doi: 10.1021/acschembio.4c00601. Epub 2024 Dec 23.
2
Practical Guidance for Developing Small-Molecule Optical Probes for In Vivo Imaging.用于体内成像的小分子光学探针开发实用指南
Mol Imaging Biol. 2023 Feb;25(1):240-264. doi: 10.1007/s11307-023-01800-1. Epub 2023 Feb 6.
3
Comparison of Bioluminescent Substrates in Natural Infection Models of Neglected Parasitic Diseases.比较忽视寄生虫病自然感染模型中的生物发光底物。
Int J Mol Sci. 2022 Dec 16;23(24):16074. doi: 10.3390/ijms232416074.
4
Novel caged luciferin derivatives can prolong bioluminescence imaging and .新型笼形荧光素衍生物可延长生物发光成像时间，并且……（原文此处不完整）
RSC Adv. 2018 May 30;8(35):19596-19599. doi: 10.1039/c8ra02312c. eCollection 2018 May 25.
5
NBD-based synthetic probes for sensing small molecules and proteins: design, sensing mechanisms and biological applications.基于 NBD 的小分子和蛋白质的合成探针：设计、传感机制和生物应用。
Chem Soc Rev. 2021 Jul 5;50(13):7436-7495. doi: 10.1039/d0cs01096k.
6
Molecular Design of d-Luciferin-Based Bioluminescence and 1,2-Dioxetane-Based Chemiluminescence Substrates for Altered Output Wavelength and Detecting Various Molecules.基于 d-荧光素的生物发光和 1,2-二氧杂环乙烷的化学发光底物的分子设计，用于改变输出波长和检测各种分子。
Molecules. 2021 Mar 15;26(6):1618. doi: 10.3390/molecules26061618.
7
Development and Applications of Bioluminescent and Chemiluminescent Reporters and Biosensors.生物发光和化学发光报告基因和生物传感器的发展与应用。
Annu Rev Anal Chem (Palo Alto Calif). 2019 Jun 12;12(1):129-150. doi: 10.1146/annurev-anchem-061318-115027. Epub 2019 Feb 20.
8
Lessons Learned from Luminous Luciferins and Latent Luciferases.从发光萤光素和潜伏萤光酶中吸取的教训。
ACS Chem Biol. 2018 Jul 20;13(7):1734-1740. doi: 10.1021/acschembio.7b00964. Epub 2018 Feb 19.
9
Pyridone Luciferins and Mutant Luciferases for Bioluminescence Imaging.吡咯酮荧光素和突变荧光素酶用于生物发光成像。
Chembiochem. 2018 Mar 2;19(5):470-477. doi: 10.1002/cbic.201700542. Epub 2018 Jan 31.
10
Enzymatic Self-Assembly Confers Exceptionally Strong Synergism with NF-κB Targeting for Selective Necroptosis of Cancer Cells.酶促自组装赋予与 NF-κB 靶向的异常强大协同作用，用于癌细胞的选择性坏死。
J Am Chem Soc. 2018 Feb 14;140(6):2301-2308. doi: 10.1021/jacs.7b12368. Epub 2018 Feb 6.
本文引用的文献
1
In vivo bioluminescent imaging (BLI): noninvasive visualization and interrogation of biological processes in living animals.体内生物发光成像（BLI）：在活体动物中对生物过程进行非侵入性可视化和检测。
Sensors (Basel). 2011;11(1):180-206. doi: 10.3390/s110100180. Epub 2010 Dec 28.
2
Bioluminescence resonance energy transfer (BRET) imaging of protein-protein interactions within deep tissues of living subjects.生物发光共振能量转移（BRET）在活体深层组织中蛋白质-蛋白质相互作用的成像。
Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12060-5. doi: 10.1073/pnas.1100923108. Epub 2011 Jul 5.
3
NMR of insensitive nuclei enhanced by dynamic nuclear polarization.通过动态核极化增强的不灵敏核的核磁共振
Chimia (Aarau). 2011;65(4):260-3.
4
Aminoluciferins as functional bioluminogenic substrates of firefly luciferase.氨基荧光素作为萤火虫荧光素酶的功能生物发光底物。
Chem Asian J. 2011 Jul 4;6(7):1800-10. doi: 10.1002/asia.201000873. Epub 2011 Mar 17.
5
Robust light emission from cyclic alkylaminoluciferin substrates for firefly luciferase.环状烷基氨荧光素底物的萤火虫荧光素酶的强发光。
J Am Chem Soc. 2010 Oct 6;132(39):13586-7. doi: 10.1021/ja104525m.
6
Kinetics of yttrium-ligand complexation monitored using hyperpolarized (89)Y as a model for gadolinium in contrast agents.使用超极化 (89)Y 作为对比剂中钆的模型监测钇配体络合动力学。
J Am Chem Soc. 2010 Apr 14;132(14):5006-7. doi: 10.1021/ja1013954.
7
Structure and spectroscopy of oxyluciferin, the light emitter of the firefly bioluminescence.氧化荧光素（萤火虫生物发光的发光物质）的结构与光谱学
J Am Chem Soc. 2009 Aug 19;131(32):11590-605. doi: 10.1021/ja904309q.
8
In vivo bioluminescence imaging of furin activity in breast cancer cells using bioluminogenic substrates.利用生物发光底物对乳腺癌细胞中弗林蛋白酶活性进行体内生物发光成像。
Bioconjug Chem. 2009 Aug 19;20(8):1660-6. doi: 10.1021/bc9002508. Epub 2009 Jul 31.
9
A redshifted codon-optimized firefly luciferase is a sensitive reporter for bioluminescence imaging.一种经过密码子优化的红移萤火虫荧光素酶是用于生物发光成像的灵敏报告基因。
Photochem Photobiol Sci. 2009 Jan;8(1):52-6. doi: 10.1039/b814566k. Epub 2008 Oct 29.
10
Advances in bioluminescence imaging of live animal models.活体动物模型生物发光成像的进展。
Curr Opin Biotechnol. 2009 Feb;20(1):45-53. doi: 10.1016/j.copbio.2009.01.007. Epub 2009 Feb 23.
Zotero 插件