Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
J Am Geriatr Soc. 2012 Mar;60(3):485-92. doi: 10.1111/j.1532-5415.2011.03867.x. Epub 2012 Feb 21.
To examine the independent association between five stages of activities of daily living (ADLs) and mortality after accounting for known diagnostic and sociodemographic risk factors.
For five stages of ADLs (0 to IV), determined according to the severity and pattern of ADL limitations, unadjusted life expectancies and adjusted associations with mortality were estimated using a Cox proportional hazards regression model.
Community.
Nine thousand four hundred forty-seven participants aged 70 and older from the second Longitudinal Study of Aging.
One-, 5-, and 10-year survival and time to death.
Median life expectancy was 10.6 years for participants with no ADL limitations and 6.5, 5.1, 3.8, and 1.6 years for those at ADL stages I, II, III, and IV, respectively. The sociodemographic- and diagnostic-adjusted hazard of death at 1 year was five times as great at stage IV as at stage 0 (hazard ratio = 5.6, 95% confidence interval = 3.8-8.3). The associations between ADL stage and mortality declined over time but remained statistically significant at 5 and 10 years.
ADL stage continued to explain mortality risk after adjusting for known risk factors including advanced age, stroke, and cancer. ADL stages might aid clinical care planning and policy as a powerful prognostic indicator particularly of short-term mortality, improving on current ADL measures by profiling activity limitations of relevance to determining community support needs.
在考虑已知诊断和社会人口学风险因素的情况下,研究日常生活活动(ADL)五个阶段与死亡率之间的独立关联。
根据 ADL 限制的严重程度和模式,将 ADL 分为五个阶段(0 到 IV 级),使用 Cox 比例风险回归模型估计未经调整的预期寿命和与死亡率的调整关联。
社区。
来自第二次老龄化纵向研究的 9447 名 70 岁及以上的参与者。
1 年、5 年和 10 年的生存率和死亡时间。
无 ADL 限制的参与者的中位预期寿命为 10.6 年,而 ADL 阶段 I、II、III 和 IV 的参与者的预期寿命分别为 6.5、5.1、3.8 和 1.6 年。经过社会人口学和诊断调整后,1 年时死亡的风险在第四阶段是第 0 阶段的五倍(风险比=5.6,95%置信区间=3.8-8.3)。ADL 阶段与死亡率之间的关联随着时间的推移而下降,但在 5 年和 10 年时仍具有统计学意义。
在调整了已知风险因素(包括高龄、中风和癌症)后,ADL 阶段仍然可以解释死亡率风险。ADL 阶段可能有助于临床护理计划和政策制定,作为一个强大的预后指标,特别是对短期死亡率的预测,通过分析与确定社区支持需求相关的活动限制,改善当前的 ADL 测量方法。