Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
J Gynecol Oncol. 2012 Jan;23(1):53-64. doi: 10.3802/jgo.2012.23.1.53. Epub 2012 Jan 9.
The annual review of 2011 comprised 11 themes of major research achievements in gynecologic oncology including breast cancer. A potential paradigm shift in the management of ovarian cancer was reviewed through comprehensive genomic analyses and a tumor-specific new intraoperative fluorescence imaging technique using folate receptor-α targeted agent, which is expected to improve intraoperative staging and more radical cytoreduction. In addition, updates of bevacizumab and poly (ADP-ribose) polymerase inhibitors, risk-reducing salpingo-oophorectomy, and risk evaluation of pelvic mass were discussed. Regarding cervical cancer, this review covered new findings on human papillomavirus vaccines and human papillomavirus tests as well as the current status of clinical trials on locally advanced cervical cancer. The promising role of sentinel lymph node biopsy in the management of early stage endometrial cancer was followed by two notable clinical researches on: exemestane, an aromatase inhibitor, for the prevention of breast cancer and eribulin, a non-taxane microtubule dynamics inhibitor for the treatment of metastatic breast cancer. Lastly, in premenopausal women with breast cancer, the effect of gonadotropin-releasing hormone analogue on the occurrence of chemotherapy-induced early menopause was discussed.
2011 年的年度综述包括 11 个妇科肿瘤学的主要研究成果主题，包括乳腺癌。通过全面的基因组分析和使用叶酸受体-α靶向剂的肿瘤特异性新术中荧光成像技术，对卵巢癌的管理进行了潜在的范式转变，预计这将改善术中分期和更激进的细胞减灭术。此外，还讨论了贝伐单抗和多聚（ADP-核糖）聚合酶抑制剂、降低风险的输卵管卵巢切除术以及盆腔肿块风险评估的更新。关于宫颈癌，本综述涵盖了人乳头瘤病毒疫苗和人乳头瘤病毒检测的新发现，以及局部晚期宫颈癌临床试验的现状。前哨淋巴结活检在早期子宫内膜癌管理中的有前途的作用之后，跟进了两项关于芳香酶抑制剂依西美坦用于预防乳腺癌和非紫杉类微管动力学抑制剂埃博霉素用于治疗转移性乳腺癌的显著临床研究。最后，在患有乳腺癌的绝经前妇女中，讨论了促性腺激素释放激素类似物对化疗引起的早绝经发生的影响。
