富含多酚的白槿（锦葵科）部分对复方新诺明耐药菌的抗菌活性。
Antimicrobial activity of polyphenol-rich fractions from Sida alba L. (Malvaceae) against co-trimoxazol-resistant bacteria strains.
机构信息
Laboratoire de Biochimie et Chimie Appliquées-LABIOCA, UFR/SVT, Université de Ouagadougou, 09 BP 848 Ouagadougou 09, Burkina Faso.
出版信息
Ann Clin Microbiol Antimicrob. 2012 Feb 24;11:5. doi: 10.1186/1476-0711-11-5.
BACKGROUND
The increased resistance of microorganisms to the currently used antimicrobials has lead to the evaluation of other agents that might have antimicrobial activity. Medicinal plants are sources of phytochemicals which are able to initiate different biological activities including antimicrobials
MATERIALS AND METHODS
In vitro antibacterial (MIC, MBC and time-kill studies) of polyphenol-rich fractions from Sida alba L. (Malvaceae) was assessed using ten bacteria strains (Gram-negative and Gram-positive).
RESULTS
All test bacteria were susceptible to the polyphenol-rich fractions. Time-kill results showed that after 5 h exposition there was no viable microorganism in the initial inoculum and the effect of polyphenol-rich fractions was faster on Enterococcus faecalis (Gram-positive bacterium) comparatively to the other bacteria strains.
CONCLUSION
The data analysis indicates that the tested of polyphenol-rich fractions has significant effects when compared with the standard antibiotic. These results therefore justify the traditional use of sida alba L., alone or in combination with other herbs to treat bacterial infections.
背景
由于微生物对目前使用的抗菌药物的耐药性增加，人们开始评估其他可能具有抗菌活性的药物。药用植物是植物化学物质的来源，这些物质能够引发不同的生物活性，包括抗菌活性。
材料和方法
采用十种细菌菌株（革兰氏阴性菌和革兰氏阳性菌）评估富含多酚的 Sida alba L.（锦葵科）部分的体外抗菌作用（MIC、MBC 和杀菌动力学研究）。
结果
所有测试细菌均对富含多酚的部分敏感。杀菌动力学结果表明，在 5 小时暴露后，初始接种物中没有存活的微生物，与其他细菌菌株相比，富含多酚的部分对粪肠球菌（革兰氏阳性菌）的作用更快。
结论
数据分析表明，与标准抗生素相比，测试的富含多酚的部分具有显著的效果。因此，这些结果证明了单独使用或与其他草药结合使用治疗细菌感染的传统用途。
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