Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, United States.
Neurosci Lett. 2012 Jun 25;519(2):103-14. doi: 10.1016/j.neulet.2012.02.027. Epub 2012 Feb 16.
Natural biomaterials are well positioned to play a significant role in the development of the next generation of biomaterials for nervous system repair. These materials are derived from naturally occurring substances and are highly diverse and versatile. They are generally biocompatible and are well tolerated in vivo, and therefore have a high potential to be successful as part of clinical repair strategies in the nervous system. Here we review recent reports on acellular tissue grafts, collagen, hyaluronan, fibrin, and agarose in their use to repair the nervous system. In addition, newly developed advanced fabrication techniques to further develop the next generation natural biomaterials-based therapeutic devices are discussed.
天然生物材料在开发下一代神经系统修复用生物材料方面具有重要作用。这些材料源自天然存在的物质，具有高度的多样性和多功能性。它们通常具有生物相容性，在体内具有良好的耐受性，因此作为神经系统临床修复策略的一部分具有很高的成功潜力。本文综述了近年来关于去细胞组织移植物、胶原、透明质酸、纤维蛋白和琼脂糖在修复神经系统中的应用。此外，还讨论了新开发的先进制造技术，以进一步开发基于下一代天然生物材料的治疗设备。
