Hussain Md Sarfaraj, Fareed Sheeba, Ansari Saba, Rahman Md Akhlaquer, Ahmad Iffat Zareen, Saeed Mohd
Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India.
J Pharm Bioallied Sci. 2012 Jan;4(1):10-20. doi: 10.4103/0975-7406.92725.
Plants are the tremendous source for the discovery of new products with medicinal importance in drug development. Today several distinct chemicals derived from plants are important drugs, which are currently used in one or more countries in the world. Secondary metabolites are economically important as drugs, flavor and fragrances, dye and pigments, pesticides, and food additives. Many of the drugs sold today are simple synthetic modifications or copies of the naturally obtained substances. The evolving commercial importance of secondary metabolites has in recent years resulted in a great interest in secondary metabolism, particularly in the possibility of altering the production of bioactive plant metabolites by means of tissue culture technology. Plant cell and tissue culture technologies can be established routinely under sterile conditions from explants, such as plant leaves, stems, roots, and meristems for both the ways for multiplication and extraction of secondary metabolites. In vitro production of secondary metabolite in plant cell suspension cultures has been reported from various medicinal plants, and bioreactors are the key step for their commercial production. Based on this lime light, the present review is aimed to cover phytotherapeutic application and recent advancement for the production of some important plant pharmaceuticals.
植物是药物开发中发现具有药用价值新产品的巨大来源。如今，几种源自植物的独特化学物质已成为重要药物，目前在世界上一个或多个国家使用。次生代谢产物在经济上作为药物、香料、染料和色素、农药及食品添加剂具有重要意义。当今销售的许多药物都是天然获得物质的简单合成修饰或复制品。近年来，次生代谢产物不断演变的商业重要性引发了人们对次生代谢的极大兴趣，尤其是通过组织培养技术改变生物活性植物代谢产物产量的可能性。植物细胞和组织培养技术可以在无菌条件下从外植体（如植物叶片、茎、根和分生组织）常规建立，用于次生代谢产物的增殖和提取。各种药用植物的植物细胞悬浮培养物中已报道了次生代谢产物的体外生产，生物反应器是其商业化生产的关键步骤。基于此亮点，本综述旨在涵盖一些重要植物药物的植物治疗应用及最新进展。
