University of Reims Champagne-Ardenne, Reims, France.
Dement Geriatr Cogn Disord. 2012;33(1):11-7. doi: 10.1159/000333070. Epub 2012 Feb 22.
The aim of this study was to identify the factors associated with differences between how Alzheimer's disease (AD) patients and their caregivers rate the patient's health-related quality of life (QoL).
Cross-sectional, multicentre study. Patients were 65 years or more, suffering from mild to moderate AD, native French speakers, with a main caregiver. Interrater agreement of the QoL-AD was assessed using the intraclass coefficient. A generalised linear model was used to identify factors related to the difference in health-related QoL scores between patients and their caregivers.
The 122 patients of the study were 82 ± 6 years old and mainly women (69%). Independent factors related to the difference between patients and caregivers were: Mini Mental State Exam score (β = 0.32; 95% CI = 0.05-0.59); instrumental activities of daily living score (β = -0.61; 95% CI = -1.14 to -0.07); total Neuropsychiatric Inventory score (β = 0.10; 95% CI = 0.05-0.59), and Zarit's burden score (β = 0.09; 95% CI = 0.01-0.17).
Practitioners must take into account the trend towards underestimation when health-related QoL is rated by caregivers or proxies.
本研究旨在确定阿尔茨海默病（AD）患者及其照料者对患者健康相关生活质量（QoL）评分差异相关的因素。
这是一项横断面、多中心研究。患者年龄在 65 岁及以上，患有轻度至中度 AD，母语为法语，有主要照料者。采用组内相关系数评估 QoL-AD 的评分者间一致性。采用广义线性模型确定与患者和照料者之间健康相关 QoL 评分差异相关的因素。
研究中的 122 名患者年龄为 82±6 岁，主要为女性（69%）。与患者和照料者之间差异相关的独立因素包括：简易精神状态检查评分（β=0.32；95%置信区间：0.05-0.59）；工具性日常生活活动评分（β=-0.61；95%置信区间：-1.14 至-0.07）；总体神经精神问卷评分（β=0.10；95%置信区间：0.05-0.59）和 Zarit 负担评分（β=0.09；95%置信区间：0.01-0.17）。
当健康相关 QoL 由照料者或代理人评分时，临床医生必须考虑到低估的趋势。
