Department of Gynecological Endocrinology, Clinic of Gynecology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Gynecol Endocrinol. 2012 Sep;28(9):703-9. doi: 10.3109/09513590.2011.650772. Epub 2012 Mar 2.
The systematic review examines whether Cimicifuga racemosa (CR), Hypericum perforatum (HP), Agnus castus, vitamins and minerals, either as monotherapy or in combination, have an evidence-based impact on vasomotor, genital and psychological climacteric complaints. DATA SOURCES AND METHODS OF STUDY SELECTION: We searched in the databases EMBASE, OVID and PubMed using the keywords "vasomotor symptoms, hot flashes, vaginal atrophy, psychological problems, endometrium, sleep, concentration, cognition in combination with vitamins, multivitamins, minerals, multiminerals, black cohosh, Cimicifuga, Agnus castus, chasteberry, chaste tree, monk's pepper and menopause" for randomized controlled trials (RCT). Relevant studies were reviewed by four independent reviewers qualitatively.
Most of the studies with a comparison of CR vs. placebo do not show an evidence-based significant effect of CR on climacteric symptoms. The combination of CR and HP shows an improvement of climacteric complaints in comparison to placebo. In some RCTs, there was no significant difference between CR and hormone-replacement therapy. The combination of HP and Agnus castus showed no significant difference in the treatment of climacteric complaints.
CR monotherapy as well as HP and Agnus castus showed no better effect than placebo. The combination of CR with HP demonstrated a positive effect on climacteric complaints.
系统评价检查黑升麻（CR）、贯叶金丝桃（HP）、牡荆、维生素和矿物质是否具有循证依据，能改善血管舒缩、生殖和心理绝经期症状。
我们使用关键词“血管舒缩症状、热潮红、阴道萎缩、心理问题、子宫内膜、睡眠、注意力、认知与维生素、多种维生素、矿物质、多种矿物质、黑升麻、升麻属、牡荆、贞节莓、贞节树、胡椒、更年期”在 EMBASE、OVID 和 PubMed 数据库中进行了检索，以寻找随机对照试验（RCT）。四名独立评审员对相关研究进行了定性审查。
大多数比较 CR 与安慰剂的研究均未显示 CR 对绝经期症状有循证依据的显著影响。CR 与 HP 的联合应用与安慰剂相比改善了绝经期症状。在一些 RCT 中，CR 与激素替代疗法之间无显著差异。HP 和牡荆的联合应用在治疗绝经期症状方面无显著差异。
CR 单一疗法以及 HP 和牡荆的应用均不比安慰剂更有效。CR 与 HP 的联合应用对绝经期症状有积极影响。
