Goñi-Moreno Angel, Amos Martyn
School of Computing, Mathematics and Digital Technology, Manchester Metropolitan University, United Kingdom.
Biosystems. 2012 Jul;109(1):52-6. doi: 10.1016/j.biosystems.2012.02.001. Epub 2012 Feb 23.
In this paper we consider the problem of representation and measurement in genetic circuits, and investigate how they can affect the reliability of engineered systems. We propose a design scheme, based on the notion of continuous computation, which addresses these issues. We illustrate the methodology by showing how a concept from computer architecture (namely, branch prediction) may be implemented in vivo, using a distributed approach. Simulation results confirm the in-principle feasibility of our method, and offer valuable insights into its future laboratory validation.
在本文中，我们考虑了基因回路中的表示和测量问题，并研究了它们如何影响工程系统的可靠性。我们基于连续计算的概念提出了一种设计方案，以解决这些问题。我们通过展示计算机体系结构中的一个概念（即分支预测）如何使用分布式方法在体内实现来说明该方法。仿真结果证实了我们方法在原理上的可行性，并为其未来的实验室验证提供了有价值的见解。
