Am J Gastroenterol. 2012 Mar;107(3):448-50. doi: 10.1038/ajg.2011.465.
Ohman et al. report increased fecal granins in patients with irritable bowel syndrome (IBS). Several interesting questions arise from their observations. Are the granins a cause of the pathophysiology or phenotype in IBS? Is the elevation of granins specific to IBS? What is the cause of increased fecal granin levels? Can fecal granin levels be used to diagnose IBS? Are increased fecal granins an expression of intestinal or colonic irritation? This paper adds to the body of evidence suggesting there are gastrointestinal disturbances in IBS; understanding these disturbances may provide clues to its pathogenesis and optimize management.
奥曼等人报告称，肠易激综合征（IBS）患者的粪便颗粒增多。他们的观察结果引发了一些有趣的问题。颗粒是 IBS 病理生理学或表型的原因吗？颗粒的升高是否特异性地存在于 IBS 中？粪便颗粒水平升高的原因是什么？粪便颗粒水平能否用于诊断 IBS？粪便颗粒增多是否是肠道或结肠刺激的表现？本文增加了支持 IBS 存在胃肠道紊乱的证据；了解这些紊乱可能为其发病机制提供线索，并优化管理。
