Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
Eur J Epidemiol. 2012 Mar;27(3):173-85. doi: 10.1007/s10654-012-9668-8. Epub 2012 Mar 3.
The prevalence of cardiovascular diseases is rising. Therefore, adequate risk prediction and identification of its determinants is increasingly important. The Rotterdam Study is a prospective population-based cohort study ongoing since 1990 in the city of Rotterdam, The Netherlands. One of the main targets of the Rotterdam Study is to identify the determinants and prognosis of cardiovascular diseases. Case finding in epidemiological studies is strongly depending on various sources of follow-up and clear outcome definitions. The sources used for collection of data in the Rotterdam Study are diverse and the definitions of outcomes in the Rotterdam Study have changed due to the introduction of novel diagnostics and therapeutic interventions. This article gives the methods for data collection and the up-to-date definitions of the cardiac outcomes based on international guidelines, including the recently adopted cardiovascular disease mortality definitions. In all, detailed description of cardiac outcome definitions enhances the possibility to make comparisons with other studies in the field of cardiovascular research and may increase the strength of collaborations.
心血管疾病的患病率正在上升。因此，充分的风险预测和确定其决定因素变得越来越重要。鹿特丹研究是一项自 1990 年以来在荷兰鹿特丹市进行的前瞻性基于人群的队列研究。鹿特丹研究的主要目标之一是确定心血管疾病的决定因素和预后。流行病学研究中的病例发现强烈依赖于各种随访来源和明确的结局定义。鹿特丹研究中用于数据收集的来源多种多样，由于新型诊断和治疗干预措施的引入，鹿特丹研究中的结局定义也发生了变化。本文介绍了基于国际指南的数据收集方法以及最新的心脏结局定义，包括最近采用的心血管疾病死亡率定义。总之，详细描述心脏结局定义提高了与心血管研究领域其他研究进行比较的可能性，并可能增强合作的力度。
