Department of Orthopedics, Chinese General Hospital of People's Liberation Army, Bejing, China.
Clin Orthop Relat Res. 2012 Aug;470(8):2235-43. doi: 10.1007/s11999-012-2293-8. Epub 2012 Mar 1.
Most patients with displaced femoral neck fractures are treated by THA and hemiarthroplasty, but it remains uncertain which if either is associated with better function and lower risks of complications.
QUESTIONS/PURPOSES: We performed a meta-analysis of randomized controlled trials (RCTs) to determine whether THA was associated with lower rates of reoperations, mortality, complications, and better function compared with hemiarthroplasty.
We searched the PubMed, Embase, Chinese Biomedicine Literature, and Cochrane Register of Controlled Trials databases and identified 12 RCTs (including a total of 1320 patients) for meta-analysis. Risk ratios (RRs) and weighted mean differences (WMDs) from each trial were pooled using random-effects or fixed-effects models depending on the heterogeneity of the included studies.
THA was associated with a lower risk of subsequent reoperations compared with hemiarthroplasty (RR = 0.53; 95% CI, 0.34-0.84). There was no difference in mortality between patients undergoing THA and hemiarthroplasty (RR = 0.81; 95% CI, 0.60-1.09). For complications, there was a higher risk of dislocation in patients undergoing THA (RR = 1.99; 95% CI, 1.26-3.15), but there were no differences in local infections (RR = 1.60; 95% CI, 0.74-3.46) and general complications (RR = 1.15; 95% CI, 0.91-1.45). Patients with THA had higher Harris hip scores at 1 year (WMD = 3.81; 95% CI, 0.87-6.74) and at 3 or 4 years (WMD = 10.07; 95% CI, 6.92-13.21).
Despite more dislocations, THA can benefit patients with displaced femoral neck fractures with a lower reoperation rate and higher functional scores.
大多数移位型股骨颈骨折患者接受全髋关节置换术(THA)和人工股骨头置换术(Hemiarthroplasty)治疗,但尚不确定哪种方法(如果有的话)与更好的功能和更低的并发症风险相关。
问题/目的:我们对随机对照试验(RCTs)进行了荟萃分析,以确定与人工股骨头置换术相比,THA 是否与更低的再手术率、死亡率、并发症发生率和更好的功能相关。
我们检索了 PubMed、Embase、中国生物医学文献数据库和 Cochrane 对照试验登记数据库,并对 12 项 RCT(共纳入 1320 名患者)进行了荟萃分析。使用随机效应或固定效应模型汇总每个试验的风险比(RR)和加权均数差(WMD),具体取决于纳入研究的异质性。
THA 与人工股骨头置换术相比,再手术风险较低(RR=0.53;95%CI,0.34-0.84)。THA 组与人工股骨头置换术组患者的死亡率无差异(RR=0.81;95%CI,0.60-1.09)。在并发症方面,THA 组患者脱位风险更高(RR=1.99;95%CI,1.26-3.15),但局部感染(RR=1.60;95%CI,0.74-3.46)和一般并发症(RR=1.15;95%CI,0.91-1.45)发生率无差异。THA 组患者在 1 年(WMD=3.81;95%CI,0.87-6.74)和 3 或 4 年(WMD=10.07;95%CI,6.92-13.21)时的 Harris 髋关节评分更高。
尽管脱位风险更高,但 THA 可以使移位型股骨颈骨折患者受益,降低再手术率,提高功能评分。