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灵芝多糖对骨髓抑制小鼠骨髓生成的促进作用

Promotion of Myelopoiesis in Myelosuppressed Mice by Ganoderma lucidum Polysaccharides.

作者信息

Zhu Xiao-Ling, Liu Ji-Hong, Li Wei-Dong, Lin Zhi-Bin

机构信息

Department of Pharmacology, School of Basic Medical Science, Peking University Health Science Center Beijing, China.

出版信息

Front Pharmacol. 2012 Feb 24;3:20. doi: 10.3389/fphar.2012.00020. eCollection 2012.

DOI:10.3389/fphar.2012.00020
PMID:22403542
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3288721/
Abstract

Our previous studies demonstrated that Ganoderma lucidum polysaccharides (Gl-PS) exhibit potent immunomodulating effects. Immunomodulation plays an important role in hematopoiesis. To investigate the possible mechanism by which Gl-PS promote myelopoiesis during myelosuppression induced by cyclophosphamide, mice were injected intraperitoneally (i.p.) once daily with 2.5 mg/kg of Gl-PS for 10 days and were treated i.p. once daily with cyclophosphamide (100 mg/kg) on days 2 through 4. In the present study in vivo and in vitro, we find that Gl-PS selectively bind to bone marrow stromal cells, stimulate the secretion of hematopoietic growth factors, and enhance the clonogenic activities of hematopoietic and stromal cells to promote hematopoiesis in myelosuppressed mice.

摘要

我们之前的研究表明，灵芝多糖（Gl-PS）具有强大的免疫调节作用。免疫调节在造血过程中发挥着重要作用。为了研究Gl-PS在环磷酰胺诱导的骨髓抑制期间促进骨髓生成的可能机制，小鼠每天腹腔注射（i.p.）2.5mg/kg的Gl-PS，持续10天，并在第2至4天每天腹腔注射一次环磷酰胺（100mg/kg）。在本体内和体外研究中，我们发现Gl-PS选择性地与骨髓基质细胞结合，刺激造血生长因子的分泌，并增强造血和基质细胞的克隆形成活性，以促进骨髓抑制小鼠的造血功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799f/3288721/7f73a7506002/fphar-03-00020-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799f/3288721/c82fedcb8632/fphar-03-00020-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799f/3288721/cfbcbf916b88/fphar-03-00020-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799f/3288721/604c8d3a7005/fphar-03-00020-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799f/3288721/7f73a7506002/fphar-03-00020-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799f/3288721/c82fedcb8632/fphar-03-00020-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799f/3288721/cfbcbf916b88/fphar-03-00020-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799f/3288721/604c8d3a7005/fphar-03-00020-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799f/3288721/7f73a7506002/fphar-03-00020-g004.jpg

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