Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Instituto de Nutrição Bloco J-2° andar, Rio de Janeiro 21941-902, Brazil.
Prostaglandins Leukot Essent Fatty Acids. 2012 Apr;86(4-5):167-74. doi: 10.1016/j.plefa.2012.03.001. Epub 2012 Mar 22.
Pregnant rats received soybean (SO), olive (OO), fish (FO) and linseed (LO) oil diets from conception to d12 of gestation (early diets) and standard diet thereafter. At d12 and d20 the lipoprotein lipase (LPL) activity was evaluated in maternal adipose tissues (ATs). Fatty Acid (FA) profile was determined in maternal lumbar AT (LAT), in milk and in pup's plasma and brain. LPL activity was higher in ATs at d12 than d20, all groups presenting hypertriglyceridemia at d20. At d12, the LO diet resulted higher LPL activity and incorporation of 18:3 n-3 into LAT. FA profile in maternal LAT at d20 and colostrum was similar to early diets, reflected also in FA composition of pup's plasma. In FO, brain phospholipids had higher 22:6 n-3 without affecting arachidonic acid. These results suggest that specifics dietary FA in early pregnancy modulates lipid metabolism and the provision of LC-PUFA in milk and pups brain.
妊娠大鼠从受孕到妊娠第 12 天（早期饮食）接受大豆（SO）、橄榄油（OO）、鱼（FO）和亚麻籽油（LO）饮食，此后接受标准饮食。在妊娠第 12 天和第 20 天，评估母体脂肪组织（AT）中的脂蛋白脂肪酶（LPL）活性。在母体腰椎脂肪组织（LAT）、乳汁和幼崽血浆和大脑中测定脂肪酸（FA）谱。与第 20 天相比，所有组在第 12 天的 AT 中 LPL 活性更高，均出现高三酰甘油血症。在第 12 天，LO 饮食导致 LPL 活性更高，18:3n-3 掺入 LAT。第 20 天母体 LAT 和初乳的 FA 谱与早期饮食相似，也反映在幼崽血浆的 FA 组成中。在 FO 中，脑磷脂中的 22:6n-3 更高，而不会影响花生四烯酸。这些结果表明，妊娠早期特定的膳食 FA 可调节脂质代谢，并为乳汁和幼崽大脑提供 LC-PUFA。
