Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
Sports Med. 2012 May 1;42(5):367-79. doi: 10.2165/11598480-000000000-00000.
This systematic review aims to get insight into the feasibility of cardiopulmonary exercise testing (CPET) in patients with cancer prior to a physical exercise programme. We will focus on quality (defined as the adherence to international guidelines for methods of CPET) and safety of CPET. Furthermore, we compare the peak oxygen uptake (·VO(2peak)) values of patients with cancer with reference values for healthy persons to put these values into a clinical perspective. A computer aided search with 'cardiopulmonary exercise testing' and 'cancer' using MEDLINE, EMBASE, Pedro, CINAHL® and SPORTDiscus™ was carried out. We included studies in which CPET with continuous gas exchange analysis has been performed prior to a physical exercise programme in adults with cancer. Twenty studies describing 1158 patients were eligible. Reported adherence to international recommendations for CPET varied per item. In most studies, the methods of CPET were not reported in detail. Adverse events occurred in 1% of patients. The percentage ·VO(2peak) of reference values for healthy persons varied between 65% and 89% for tests before treatment, between 74% and 96% for tests during treatment and between 52% and 117% for tests after treatment. Our results suggest that CPET is feasible and seems to be safe for patients with cancer prior to a physical exercise programme. We recommend that standard reporting and quality guidelines should be followed for CPET methods. The decreased ·VO(2peak) values of patients with cancer indicate that physical exercise should be implemented in their standard care.
本系统评价旨在深入了解癌症患者在进行体力活动计划之前进行心肺运动测试（CPET）的可行性。我们将重点关注 CPET 的质量（定义为对 CPET 方法的国际指南的遵循程度）和安全性。此外，我们将比较癌症患者的峰值摄氧量（·VO(2peak)）值与健康人群的参考值，以便将这些值置于临床视角下。使用 MEDLINE、EMBASE、Pedro、CINAHL® 和 SPORTDiscus™，通过计算机辅助搜索“心肺运动测试”和“癌症”，进行了搜索。我们纳入了在癌症成人中进行体力活动计划之前进行 CPET 并进行连续气体交换分析的研究。有 20 项研究描述了 1158 名患者符合条件。报告的 CPET 对国际建议的遵循程度因项目而异。在大多数研究中，CPET 的方法没有详细报告。不良事件发生在 1%的患者中。治疗前测试的健康人群·VO(2peak)参考值百分比在 65%至 89%之间，治疗期间测试的百分比在 74%至 96%之间，治疗后测试的百分比在 52%至 117%之间。我们的结果表明，CPET 对于癌症患者在进行体力活动计划之前是可行的，并且似乎是安全的。我们建议 CPET 方法应遵循标准报告和质量指南。癌症患者的·VO(2peak)值降低表明应将体力活动纳入他们的标准治疗中。
