Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China.
Evid Based Complement Alternat Med. 2012;2012:716459. doi: 10.1155/2012/716459. Epub 2012 Feb 6.
Tanshinone IIA (Tan IIA) is a member of the major lipophilic components extracted from the root of Salvia miltiorrhiza Bunge, which is currently used in China and other neighboring countries to treat patients suffering from myocardial infarction (MI), angina pectoris, stroke, diabetes, sepsis, and other conditions. However, Tan IIA is not easy to be absorbed through intestinal pathway. To raise the bioavailability of the herb, sodium tanshinone IIA sulfonate (STS) was developed. This paper discussed the pharmacology of Tan IIA, STS, and their potential cardioprotective effects.
丹参酮 IIA（Tan IIA）是从丹参的根部分离提取的主要脂溶性成分之一，目前在中国和其他邻国用于治疗心肌梗死（MI）、心绞痛、中风、糖尿病、败血症等疾病的患者。然而，Tan IIA 不易通过肠道途径吸收。为了提高草药的生物利用度，开发了丹参酮 IIA 磺酸钠（STS）。本文讨论了 Tan IIA、STS 的药理学及其潜在的心脏保护作用。
