人类微生物组及其对儿科学的潜在重要性。
The human microbiome and its potential importance to pediatrics.
机构信息
Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.
出版信息
Pediatrics. 2012 May;129(5):950-60. doi: 10.1542/peds.2011-2736. Epub 2012 Apr 2.
Abstract
The human body is home to more than 1 trillion microbes, with the gastrointestinal tract alone harboring a diverse array of commensal microbes that are believed to contribute to host nutrition, developmental regulation of intestinal angiogenesis, protection from pathogens, and development of the immune response. Recent advances in genome sequencing technologies and metagenomic analysis are providing a broader understanding of these resident microbes and highlighting differences between healthy and disease states. The aim of this review is to provide a detailed summary of current pediatric microbiome studies in the literature, in addition to highlighting recent findings and advancements in studies of the adult microbiome. This review also seeks to elucidate the development of, and factors that could lead to changes in, the composition and function of the human microbiome.
摘要
人体内生活着超过 1 万亿的微生物，仅胃肠道内就栖息着多种多样的共生微生物，这些微生物被认为有助于宿主营养、肠道血管生成的发育调控、防止病原体感染和免疫反应的发展。基因组测序技术和宏基因组分析的最新进展使人们对这些常驻微生物有了更广泛的了解，并突出了健康状态和疾病状态之间的差异。本综述的目的是详细总结文献中目前的儿科微生物组研究，同时强调成人微生物组研究的最新发现和进展。本综述还试图阐明人类微生物组的组成和功能的发展以及可能导致其变化的因素。
相似文献
1
The human microbiome and its potential importance to pediatrics.人类微生物组及其对儿科学的潜在重要性。
Pediatrics. 2012 May;129(5):950-60. doi: 10.1542/peds.2011-2736. Epub 2012 Apr 2.
2
Pediatric surgery and the human microbiome.小儿外科学与人类微生物组
J Pediatr Surg. 2011 Mar;46(3):577-84. doi: 10.1016/j.jpedsurg.2010.12.018.
3
The human microbiome and probiotics: implications for pediatrics.人类微生物组与益生菌：对儿科学的启示。
Ann Nutr Metab. 2013;63 Suppl 2:42-52. doi: 10.1159/000354899. Epub 2013 Nov 8.
4
Bifidobacteria and Their Health-Promoting Effects.双歧杆菌及其促进健康的作用。
Microbiol Spectr. 2017 Jun;5(3). doi: 10.1128/microbiolspec.BAD-0010-2016.
5
Necrotizing Enterocolitis Pathophysiology: How Microbiome Data Alter Our Understanding.坏死性小肠结肠炎的病理生理学：微生物组数据如何改变我们的理解。
Clin Perinatol. 2019 Mar;46(1):29-38. doi: 10.1016/j.clp.2018.10.003. Epub 2018 Dec 12.
6
Functions of intestinal microflora in children.肠道菌群在儿童中的功能。
Curr Opin Gastroenterol. 2013 Jan;29(1):31-8. doi: 10.1097/MOG.0b013e32835a3500.
7
Targeting the human microbiome with antibiotics, probiotics, and prebiotics: gastroenterology enters the metagenomics era.使用抗生素、益生菌和益生元靶向人类微生物组：胃肠病学进入宏基因组学时代。
Gastroenterology. 2009 May;136(6):2015-31. doi: 10.1053/j.gastro.2009.01.072.
8
Manipulation of the Microbiota Using Probiotics.使用益生菌对微生物群进行调控。
Adv Exp Med Biol. 2016;902:109-17. doi: 10.1007/978-3-319-31248-4_8.
9
Preterm infant nutrition, gut bacteria, and necrotizing enterocolitis.早产婴儿营养、肠道细菌与坏死性小肠结肠炎
Curr Opin Clin Nutr Metab Care. 2015 May;18(3):285-8. doi: 10.1097/MCO.0000000000000169.
10
The intestinal microbiome of infants and the use of probiotics.婴儿的肠道微生物组与益生菌的使用。
Curr Opin Pediatr. 2011 Apr;23(2):145-50. doi: 10.1097/MOP.0b013e3283444ccb.
引用本文的文献
1
Healthcare seeking behavior and antibiotic use for diarrhea among children in rural Bangladesh before seeking care at a healthcare facility.孟加拉国农村地区儿童在前往医疗机构就诊前的腹泻就医行为及抗生素使用情况。
Sci Rep. 2025 Jul 20;15(1):26359. doi: 10.1038/s41598-025-09479-w.
2
CODARFE: Unlocking the prediction of continuous environmental variables based on microbiome.CODARFE：基于微生物组实现对连续环境变量的预测
Gigascience. 2025 Jan 6;14. doi: 10.1093/gigascience/giaf055.
3
The role of plant-based dietary compounds in gut microbiota modulation in inflammatory bowel disease.植物性膳食化合物在炎症性肠病中调节肠道微生物群的作用。
Front Nutr. 2025 May 30;12:1606289. doi: 10.3389/fnut.2025.1606289. eCollection 2025.
4
Healthcare seeking behavior and antibiotic use for diarrhea among children in rural Bangladesh before seeking care at a healthcare facility.孟加拉国农村地区儿童在前往医疗机构就诊前针对腹泻的就医行为及抗生素使用情况。
Res Sq. 2025 Apr 17:rs.3.rs-5687932. doi: 10.21203/rs.3.rs-5687932/v1.
5
Exclusive breastfeeding is associated with the gut microbiome maturation in infants according to delivery mode.根据分娩方式，纯母乳喂养与婴儿肠道微生物群的成熟有关。
Gut Microbes. 2025 Dec;17(1):2493900. doi: 10.1080/19490976.2025.2493900. Epub 2025 Apr 16.
6
Understanding the complex function of gut microbiota: its impact on the pathogenesis of obesity and beyond: a comprehensive review.理解肠道微生物群的复杂功能：其对肥胖及其他疾病发病机制的影响：综述
Diabetol Metab Syndr. 2024 Dec 23;16(1):308. doi: 10.1186/s13098-024-01561-z.
7
Antibiotic Exposure and Childhood Overweight/Obesity: Evidence from Epidemiological and Experimental Studies.抗生素暴露与儿童超重/肥胖：来自流行病学和实验研究的证据。
Curr Pharm Des. 2025;31(12):934-942. doi: 10.2174/0113816128333496240911061551.
8
Investigation of the Impact of Antibiotic Administration on the Preterm Infants' Gut Microbiome Using Next-Generation Sequencing-Based 16S rRNA Gene Analysis.利用基于新一代测序的16S rRNA基因分析研究抗生素给药对早产儿肠道微生物群的影响。
Antibiotics (Basel). 2024 Oct 16;13(10):977. doi: 10.3390/antibiotics13100977.
9
Relationship between Infant Feeding and the Microbiome: Implications for Allergies and Food Intolerances.婴儿喂养与微生物群的关系：对过敏和食物不耐受的影响。
Children (Basel). 2024 Aug 22;11(8):1030. doi: 10.3390/children11081030.
10
Navigating the microbial maze: unraveling the connection between gut microbiome and pediatric kidney and urinary tract disease.探索微生物迷宫：揭示肠道微生物群与小儿肾脏及泌尿系统疾病之间的联系。
Pediatr Nephrol. 2025 Feb;40(2):339-353. doi: 10.1007/s00467-024-06357-x. Epub 2024 Jun 3.
本文引用的文献
1
Role of the commensal microbiota in normal and pathogenic host immune responses.共生微生物群在正常和致病宿主免疫反应中的作用。
Cell Host Microbe. 2011 Oct 20;10(4):311-23. doi: 10.1016/j.chom.2011.10.004.
2
Linking long-term dietary patterns with gut microbial enterotypes.将长期饮食模式与肠道微生物肠型联系起来。
Science. 2011 Oct 7;334(6052):105-8. doi: 10.1126/science.1208344. Epub 2011 Sep 1.
3
Culture enriched molecular profiling of the cystic fibrosis airway microbiome.文化富集的囊性纤维化气道微生物组分子特征分析。
PLoS One. 2011;6(7):e22702. doi: 10.1371/journal.pone.0022702. Epub 2011 Jul 28.
4
Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome.儿科肠易激综合征患者的胃肠道微生物组特征。
Gastroenterology. 2011 Nov;141(5):1782-91. doi: 10.1053/j.gastro.2011.06.072. Epub 2011 Jul 8.
5
Diversity of the human skin microbiome early in life.生命早期的人类皮肤微生物组多样性。
J Invest Dermatol. 2011 Oct;131(10):2026-32. doi: 10.1038/jid.2011.168. Epub 2011 Jun 23.
6
Fecal microbiota in premature infants prior to necrotizing enterocolitis.坏死性小肠结肠炎患儿发病前的粪便微生物群。
PLoS One. 2011;6(6):e20647. doi: 10.1371/journal.pone.0020647. Epub 2011 Jun 6.
7
Distal gut microbiota of adolescent children is different from that of adults.青少年儿童的远端肠道微生物群与成年人不同。
FEMS Microbiol Ecol. 2011 Aug;77(2):404-12. doi: 10.1111/j.1574-6941.2011.01120.x. Epub 2011 Jun 1.
8
Enterotypes of the human gut microbiome.人类肠道微生物组的肠型。
Nature. 2011 May 12;473(7346):174-80. doi: 10.1038/nature09944. Epub 2011 Apr 20.
9
The developing intestinal microbiome and its relationship to health and disease in the neonate.发育中的肠道微生物组及其与新生儿健康和疾病的关系。
J Perinatol. 2011 Apr;31 Suppl 1:S29-34. doi: 10.1038/jp.2010.172.
10
Gram negative bacteria are associated with the early stages of necrotizing enterocolitis.革兰氏阴性菌与坏死性小肠结肠炎的早期阶段有关。
PLoS One. 2011 Mar 22;6(3):e18084. doi: 10.1371/journal.pone.0018084.
Zotero 插件