Department of Operative Dentistry, University Medical Center of the Johannes Gutenberg University Mainz, Germany.
Head Face Med. 2012 Apr 5;8:12. doi: 10.1186/1746-160X-8-12.
The purpose of this long-term clinical study was to examine the additional efficacy of photodynamic therapy (PDT) to scaling and root planing (SRP) in patients with chronic periodontal disease.
A total of 22 patients (mean age: 59.3 ± 11.7 years) with chronic periodontal disease and four teeth with probing depth ≥ 5 mm were enrolled in the study. Inclusion criteria were: no systemic disease, no smoking, no pregnancy and no long-term medication. Beside the anamnesis, the following clinical parameters were assessed at baseline (one week before therapy), and one, three and six months after the therapy: bleeding on probing (BOP), plaque index (PI) probing depth (PD), and clinical attachment loss. All measurements were done by the same examiner with a fixed periodontal probe (PCP 12, Hu-Friedy) at six measurements/tooth. In each patient, two teeth were treated with SRP alone and two teeth with SRP and PDT (Periowave, Ondine Biopharma, Vancouver, Canada). The nonparametric Wilcoxon test for paired samples was used for comparison of the effect of the two treatments (p ≤ 0.05).
After both types of treatment, the number of teeth positive for BOP declined. At baseline, the CAL measured 7.2 ± 1.2 mm (SRP) or 8.1 ± 1.3 mm (SRP/PDT); one, three and six months after both types of treatment an improvement was observed. At baseline, the probing depth was 5.9 ± 0.8 mm (SRP) or 6.4 ± 0.8 mm (SRP/PDT); after six months, an improvement of 2.4 ± 0.6 mm (SRP) or 2.9 ± 0.8 mm (SRP/PDT) was found. The greater reduction of the PD, achieved by a combination of SRP/PDT, was statistically significant after six months (p = 0.007).
This clinical study demonstrates that SRP in combination with PDT seems to be effective and is therefore suitable as an adjuvant therapy to the mechanical conditioning of the periodontal pockets in patients with chronic periodontal diseases.
本长期临床研究的目的是检查光动力疗法（PDT）对慢性牙周病患者的牙周刮治和根面平整（SRP）的附加疗效。
共有 22 名（平均年龄：59.3±11.7 岁）患有慢性牙周病且有 4 颗探诊深度≥5mm 的患者纳入本研究。纳入标准为：无系统疾病、不吸烟、不怀孕和不长期服用药物。除病史外，在治疗前一周（基线）和治疗后 1、3 和 6 个月，还评估了以下临床参数：探诊出血（BOP）、菌斑指数（PI）、探诊深度（PD）和临床附着丧失。所有测量均由同一位使用固定牙周探针（PCP 12，Hu-Friedy）在每个牙的 6 个点进行。在每位患者中，两颗牙接受单独的 SRP 治疗，两颗牙接受 SRP 和 PDT（Ondine Biopharma，Vancouver，加拿大的 Periowave）治疗。使用配对样本的非参数 Wilcoxon 检验比较两种治疗方法的效果（p≤0.05）。
两种治疗方法后，探诊出血阳性的牙齿数量减少。基线时，CAL 测量值为 7.2±1.2mm（SRP）或 8.1±1.3mm（SRP/PDT）；两种治疗方法后 1、3 和 6 个月均观察到改善。基线时，探诊深度为 5.9±0.8mm（SRP）或 6.4±0.8mm（SRP/PDT）；治疗 6 个月后，SRP 组和 SRP/PDT 组的探诊深度分别改善了 2.4±0.6mm 和 2.9±0.8mm。SRP/PDT 联合治疗后 PD 的更大减小在统计学上具有显著性，在 6 个月时（p=0.007）。
本临床研究表明，SRP 联合 PDT 似乎有效，因此适合作为慢性牙周病患者牙周袋机械处理的辅助治疗。
