新型抗病毒药物阿立多的作用模式的初步研究。
Preliminary studies of the mode of action of arildone, a novel antiviral agent.
作者信息
Kuhrt M F, Fancher M J, Jasty V, Pancic F, Came P E
出版信息
Antimicrob Agents Chemother. 1979 Jun;15(6):813-9. doi: 10.1128/AAC.15.6.813.
Abstract
Arildone (also known as Win 38020), a novel aryl diketone, inhibited replication of herpes simplex virus type 2 in tissue culture by interfering with an event that occurs prior to 6 h postinfection. The inhibition could be partially reversed by washing. Although the exact mechanism of action is unknown, neither viral deoxyribonucleic acid nor viral proteins were synthesized in the presence of arildone.
摘要
阿立多（也称为Win 38020）是一种新型芳基二酮，通过干扰感染后6小时之前发生的一个事件，抑制单纯疱疹病毒2型在组织培养中的复制。这种抑制作用可通过洗涤部分逆转。尽管确切的作用机制尚不清楚，但在阿立多存在的情况下，病毒脱氧核糖核酸和病毒蛋白均未合成。
相似文献
1
Preliminary studies of the mode of action of arildone, a novel antiviral agent.新型抗病毒药物阿立多的作用模式的初步研究。
Antimicrob Agents Chemother. 1979 Jun;15(6):813-9. doi: 10.1128/AAC.15.6.813.
2
Human cytomegalovirus infections in vitro after treatment with arildone.用阿立酮治疗后体外的人巨细胞病毒感染
J Gen Virol. 1984 Dec;65 ( Pt 12):2129-39. doi: 10.1099/0022-1317-65-12-2129.
3
Antiviral activity of arildone on deoxyribonucleic acid and ribonucleic acid viruses.阿立多对脱氧核糖核酸病毒和核糖核酸病毒的抗病毒活性。
Antimicrob Agents Chemother. 1980 Aug;18(2):276-80. doi: 10.1128/AAC.18.2.276.
4
Inhibition of herpes simplex virus DNA synthesis by pokeweed antiviral protein.商陆抗病毒蛋白对单纯疱疹病毒DNA合成的抑制作用。
Antimicrob Agents Chemother. 1983 Mar;23(3):390-6. doi: 10.1128/AAC.23.3.390.
5
The role of arginine in the replication of herpes simplex virus.
J Gen Virol. 1967 Oct;1(4):471-8. doi: 10.1099/0022-1317-1-4-471.
6
Inhibition of Herpes simplex virus replication by camptothecin.喜树碱对单纯疱疹病毒复制的抑制作用。
Isr J Med Sci. 1973 Nov-Dec;9(11):1578-81.
7
Inhibition of Herpes simplex virus replication by cordycepin.虫草素对单纯疱疹病毒复制的抑制作用。
Isr J Med Sci. 1973 Nov-Dec;9(11):1581-5.
8
The effect of canavanine on herpes simplex virus replication.刀豆氨酸对单纯疱疹病毒复制的影响。
J Gen Virol. 1974 Mar;22(3):319-30. doi: 10.1099/0022-1317-22-3-319.
9
Inhibition of synthesis of herpes simplex virus deoxyribonucleic acid by a carcinogenic polycyclic aromatic hydrocarbon.
Proc Soc Exp Biol Med. 1972 Jul;140(3):1054-8. doi: 10.3181/00379727-140-36610.
10
Effect of arildone on modifications of poliovirus in vitro.
Virology. 1980 Aug;105(1):86-93. doi: 10.1016/0042-6822(80)90158-0.
引用本文的文献
1
Picornavirus inhibitors.小核糖核酸病毒抑制剂
Pharmacol Ther. 1994;64(2):215-90. doi: 10.1016/0163-7258(94)90040-x.
2
Antiviral activity of arildone on deoxyribonucleic acid and ribonucleic acid viruses.阿立多对脱氧核糖核酸病毒和核糖核酸病毒的抗病毒活性。
Antimicrob Agents Chemother. 1980 Aug;18(2):276-80. doi: 10.1128/AAC.18.2.276.
3
Antiviral activity of Win 41258-3, a pyrazole compound, against herpes simplex virus in mouse genital infection and in guinea pig skin infection.吡唑化合物Win 41258-3在小鼠生殖器感染和豚鼠皮肤感染中对单纯疱疹病毒的抗病毒活性。
Antimicrob Agents Chemother. 1981 Mar;19(3):470-6. doi: 10.1128/AAC.19.3.470.
4
Activity of 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (MDL-860) against picornaviruses in vitro.2-(3,4-二氯苯氧基)-5-硝基苯甲腈（MDL-860）在体外对微小核糖核酸病毒的活性。
Antimicrob Agents Chemother. 1982 Oct;22(4):639-42. doi: 10.1128/AAC.22.4.639.
5
Prevention of human poliovirus-induced paralysis and death in mice by the novel antiviral agent arildone.新型抗病毒药物阿立多能预防小鼠因人类脊髓灰质炎病毒导致的麻痹和死亡。
Antimicrob Agents Chemother. 1982 Dec;22(6):1022-5. doi: 10.1128/AAC.22.6.1022.
6
Disposition of arildone, an antiviral agent, after various routes of administration.抗病毒药物阿立多宁经不同给药途径后的处置情况。
Antimicrob Agents Chemother. 1982 Sep;22(3):475-81. doi: 10.1128/AAC.22.3.475.
7
A placebo-controlled trial of topical 8% arildone cream early in recurrent genital herpes.复发性生殖器疱疹早期外用8%阿立多酮乳膏的安慰剂对照试验。
Antimicrob Agents Chemother. 1986 Mar;29(3):464-7. doi: 10.1128/AAC.29.3.464.
8
In vitro activity of WIN 51711, a new broad-spectrum antipicornavirus drug.新型广谱抗微小核糖核酸病毒药物WIN 51711的体外活性
Antimicrob Agents Chemother. 1985 Jun;27(6):883-6. doi: 10.1128/AAC.27.6.883.
本文引用的文献
1
Inhibition of herpes simplex virus replication by phosphonoacetic acid.膦甲酸钠对单纯疱疹病毒复制的抑制作用。
Antimicrob Agents Chemother. 1974 Sep;6(3):360-5. doi: 10.1128/AAC.6.3.360.
2
A simple membrane fractionation method for determining the distribution of radioactivity in chemical fractions of Bacillus cereus.一种用于测定蜡样芽孢杆菌化学组分中放射性分布的简单膜分级分离方法。
Biochim Biophys Acta. 1960 Jun 17;41:80-8. doi: 10.1016/0006-3002(60)90371-1.
3
SOME CHARACTERISTICS OF THE DEOXYRIBONUCLEIC ACID FROM HERPES SIMPLEX VIRUS.单纯疱疹病毒脱氧核糖核酸的一些特性
Virology. 1963 Nov;21:353-61. doi: 10.1016/0042-6822(63)90196-x.
4
Mode of antiviral action of 5-iodouracil deoxyriboside.
J Mol Biol. 1966 Aug;19(2):320-32. doi: 10.1016/s0022-2836(66)80007-4.
5
Isolation and characterization of tubules and plasma membranes from Cytophaga columnaris.柱状噬纤维菌中小管和质膜的分离与鉴定
J Bacteriol. 1973 Jun;114(3):1309-18. doi: 10.1128/jb.114.3.1309-1318.1973.
6
Proteins specified by herpes simplex virus. XII. The virion polypeptides of type 1 strains.单纯疱疹病毒指定的蛋白质。十二。1型毒株的病毒体多肽。
J Virol. 1974 Sep;14(3):640-51. doi: 10.1128/JVI.14.3.640-651.1974.
7
Herpes simplex virus and human cytomegalovirus replication in WI-38 cells. I. Sequence of viral replication.单纯疱疹病毒和人巨细胞病毒在WI-38细胞中的复制。I. 病毒复制序列。
J Virol. 1973 Oct;12(4):919-30. doi: 10.1128/JVI.12.4.919-930.1973.
8
Herpesvirus envelopment.疱疹病毒包膜化。
J Virol. 1968 Jan;2(1):48-55. doi: 10.1128/JVI.2.1.48-55.1968.
9
Electron microscopy of herpes simplex virus. II. Sequence of development.单纯疱疹病毒的电子显微镜检查。II. 发育过程
J Virol. 1968 May;2(5):517-36. doi: 10.1128/JVI.2.5.517-536.1968.
10
Electron microscopy of herpes simplex virus. I. Entry.单纯疱疹病毒的电子显微镜观察。I. 进入
J Virol. 1968 May;2(5):507-16. doi: 10.1128/JVI.2.5.507-516.1968.
Zotero 插件