Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 104, 3584 CM, Utrecht, The Netherlands.
Reprod Toxicol. 2012 Aug;34(1):110-9. doi: 10.1016/j.reprotox.2012.03.004. Epub 2012 Mar 30.
Zearalenone (ZEN) is a mycotoxin that can be a contaminant of food and feed commodities. ZEN acts as a xenoestrogen and is considered an endocrine disruptor. Since estrogens influence oogenesis during fetal growth, the effect of ZEN on oocytes was investigated in the F1-generation. Pregnant and lactating pigs were exposed to feed naturally contaminated with ZEN (200, 500 and 1000μg/kg feed). Ovaries of F1-animals were examined for follicle development, expression of estrogen converting enzymes and estrogen receptors, and oocyte quality. In F1-newborns, ZEN did not affect follicle dynamics, but follicle integrity decreased with increasing ZEN concentrations. Expression of estrogen receptor beta mRNA increased following ZEN exposure, whereas expression of genes coding for estrogen converting enzymes remained unchanged. In F1-prepubertal gilts, follicular atresia and oocyte maturation with subsequent embryo development remained unchanged. In conclusion, ZEN reduced the quantity of healthy follicles, which may lead to premature oocyte depletion in adulthood.
玉米赤霉烯酮（ZEN）是一种真菌毒素，可能会污染食物和饲料。ZEN 具有类雌激素作用，被认为是一种内分泌干扰物。由于雌激素会影响胎儿生长过程中的卵母细胞生成，因此研究了 ZEN 对 F1 代卵母细胞的影响。怀孕和哺乳期的猪被暴露在天然污染 ZEN（200、500 和 1000μg/kg 饲料）的饲料中。检查 F1 动物的卵巢以研究卵泡发育、雌激素转化酶和雌激素受体的表达以及卵母细胞质量。在 F1 新生儿中，ZEN 并未影响卵泡动态，但随着 ZEN 浓度的增加，卵泡完整性下降。ZEN 暴露后雌激素受体 β mRNA 的表达增加，而编码雌激素转化酶的基因表达保持不变。在 F1 青春期小母猪中，卵泡闭锁和卵母细胞成熟以及随后的胚胎发育没有变化。总之，ZEN 减少了健康卵泡的数量，这可能导致成年后卵母细胞过早耗竭。
