Artois M, Charlton K M, Tolson N D, Casey G A, Knowles M K, Campbell J B
Agriculture Canada, Animal Diseases Research Institute, NEPEAN, Ontario.
Can J Vet Res. 1990 Oct;54(4):504-7.
Twenty-six meadow voles (Microtus pennsylvanicus), ten woodchucks (Marmota monax), thirteen grey squirrels (Sciurus carolinensis), thirteen ring-billed gulls (Larus delawarensis), six red-tailed hawks (Buteo jamaicensis) and eight great horned owls (Bubo virginianus) received vaccinia virus recombinant expressing the rabies virus glycoprotein (V-RG) by direct instillation into the oral cavity. Each of ten coyotes (Canis latrans) received the virus in two vaccine-laden baits. Several voles and most of the gulls died from diseases unrelated to vaccination during the observation period, but all other animals remained healthy and survived. These deaths from causes other than vaccination and the absence of any lesions suggestive of vaccinia infection indicate that it is unlikely that any animal suffered or died as a result of V-RG administration. In addition several animals showed an unexpected high level of rabies neutralizing antibodies.
通过直接滴入口腔，给26只草地田鼠（宾夕法尼亚田鼠）、10只土拨鼠（旱獭）、13只灰松鼠（卡罗来纳松鼠）、13只环嘴鸥（特拉华鸥）、6只红尾鹰（牙买加隼）和8只大角鸮（弗吉尼亚雕鸮）接种了表达狂犬病病毒糖蛋白的痘苗病毒重组体（V-RG）。10只郊狼（犬属）每只都在两个装有疫苗的诱饵中接种了该病毒。在观察期内，几只田鼠和大多数海鸥死于与疫苗接种无关的疾病，但所有其他动物都保持健康并存活下来。这些因接种疫苗以外的原因导致的死亡以及没有任何提示痘苗感染的病变表明，不太可能有任何动物因接种V-RG而受苦或死亡。此外，几只动物显示出意外高水平的狂犬病中和抗体。
