Craig S P, Day I N, Thompson R J, Craig I W
Biochemistry Department, University of Oxford, UK.
Cytogenet Cell Genet. 1990;54(1-2):71-3. doi: 10.1159/000132960.
We have localised the human cDNA for neurone-specific enolase (ENO2) to chromosome region 12p13 by in situ hybridisation. Two additional smaller peaks of hybridisation to specific chromosomal subregions were observed. That on chromosome 1p36 probably represents cross-hybridisation to the locus for nonneuronal enolase (ENO1), which has been previously localised to this chromosome and with which ENO2 shares homology. A further gene for a member of the enolase family may be responsible for the hybridisation to chromosome 17.
我们通过原位杂交将人神经元特异性烯醇化酶（ENO2）的cDNA定位于染色体区域12p13。观察到另外两个与特定染色体亚区域杂交的较小峰值。位于染色体1p36上的那个峰值可能代表与非神经元烯醇化酶（ENO1）基因座的交叉杂交，ENO1先前已定位于该染色体，且与ENO2具有同源性。烯醇化酶家族另一个成员的基因可能是与染色体17杂交的原因。
