Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Ophthalmology. 2012 Aug;119(8):1642-9. doi: 10.1016/j.ophtha.2012.01.053. Epub 2012 Apr 13.
To test whether supplementation with alternate-day vitamin E or daily vitamin C affects the incidence of the diagnosis of age-related macular degeneration (AMD) in a large-scale randomized trial of male physicians.
Randomized, double-masked, placebo-controlled trial.
We included 14 236 apparently healthy United States male physicians aged ≥50 years who did not report a diagnosis of AMD at baseline.
Participants were randomly assigned to receive 400 international units (IU) of vitamin E or placebo on alternate days, and 500 mg of vitamin C or placebo daily. Participants reported new diagnoses of AMD on annual questionnaires and medical record data were collected to confirm the reports.
Incident diagnosis of AMD responsible for a reduction in best-corrected visual acuity to ≤20/30.
After 8 years of treatment and follow-up, a total of 193 incident cases of visually significant AMD were documented. There were 96 cases in the vitamin E group and 97 in the placebo group (hazard ratio [HR], 1.03; 95% confidence interval [CI], 0.78-1.37). For vitamin C, there were 97 cases in the active group and 96 in the placebo group (HR, 0.99; 95% CI, 0.75-1.31).
In a large-scale, randomized trial of United States male physicians, alternate-day use of 400 IU of vitamin E and/or daily use of 500 mg of vitamin C for 8 years had no appreciable beneficial or harmful effect on risk of incident diagnosis of AMD.
在一项针对美国男性医生的大规模随机试验中，检验隔日补充维生素 E 或每日补充维生素 C 是否会影响年龄相关性黄斑变性（AMD）的诊断发生率。
随机、双盲、安慰剂对照试验。
我们纳入了 14236 名年龄≥50 岁、在基线时未报告 AMD 诊断的美国男性医生。
参与者被随机分配隔日接受 400 国际单位（IU）维生素 E 或安慰剂，每日接受 500 毫克维生素 C 或安慰剂。参与者在每年的问卷调查中报告新的 AMD 诊断，同时收集医疗记录数据以确认报告。
导致最佳矫正视力降至≤20/30 的 AMD 新诊断病例。
经过 8 年的治疗和随访，共记录了 193 例有明显视觉影响的 AMD 新发病例。维生素 E 组有 96 例，安慰剂组有 97 例（风险比 [HR]，1.03；95%置信区间 [CI]，0.78-1.37）。对于维生素 C，活性组有 97 例，安慰剂组有 96 例（HR，0.99；95% CI，0.75-1.31）。
在一项针对美国男性医生的大规模随机试验中，8 年内隔日使用 400IU 维生素 E 和/或每日使用 500 毫克维生素 C，对 AMD 新诊断病例的风险没有明显的有益或有害影响。
