Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Ophthalmology. 2010 Jun;117(6):1163-8. doi: 10.1016/j.ophtha.2009.10.043. Epub 2010 Feb 13.
To test whether alternate day vitamin E affects the incidence of age-related macular degeneration (AMD) in a large-scale randomized trial of women.
Randomized, double-masked, placebo-controlled trial.
Thirty-nine thousand eight hundred seventy-six apparently healthy female health professionals aged 45 years or older.
Participants were assigned randomly to receive either 600 IU of natural-source vitamin E on alternate days or placebo.
Incident AMD responsible for a reduction in best-corrected visual acuity to 20/30 or worse based on self-report confirmed by medical record review.
After 10 years of treatment and follow-up, there were 117 cases of AMD in the vitamin E group and 128 cases in the placebo group (relative risk, 0.93; 95% confidence interval, 0.72-1.19).
In a large-scale randomized trial of female health professionals, long-term alternate-day use of 600 IU of natural-source vitamin E had no large beneficial or harmful effect on risk of AMD.
在一项针对女性的大规模随机试验中，检验隔日补充维生素 E 是否会影响年龄相关性黄斑变性（AMD）的发病率。
随机、双盲、安慰剂对照试验。
39876 名年龄在 45 岁或以上的健康女性医护人员。
参与者被随机分配接受隔日服用 600IU 天然来源维生素 E 或安慰剂。
根据自我报告并经病历审查确认的最佳矫正视力下降至 20/30 或更差，判断新发 AMD。
经过 10 年的治疗和随访，维生素 E 组有 117 例 AMD，安慰剂组有 128 例（相对风险，0.93；95%置信区间，0.72-1.19）。
在一项针对女性医护人员的大规模随机试验中，长期隔日使用 600IU 天然来源维生素 E 对 AMD 的发病风险没有明显的有益或有害影响。
