García Marley, Monzote Lianet, Scull Ramón, Herrera Pedro
Department of Parasitology, Institute of Tropical Medicine "Pedro Kourí," Apdo Postal No. 601, Havana 10400, Cuba.
ISRN Pharmacol. 2012;2012:104540. doi: 10.5402/2012/104540. Epub 2012 Mar 15.
Natural products have long been providing important drug leads for infectious diseases. Leishmaniasis is a major health problem worldwide that affects millions of people especially in the developing nations. There is no immunoprophylaxis (vaccination) available for Leishmania infections, and conventional treatments are unsatisfactory; therefore, antileishmanial drugs are urgently needed. In this work, 48 alcoholic extracts from 46 Cuban plants were evaluated by an in vitro bioassay against Leishmania amazonensis. Furthermore, their toxicity was assayed against murine macrophage. The three most potent extracts against the amastigote stage of Leishmania amazonensis were from Hura crepitans, Bambusa vulgaris, and Simarouba glauca.
天然产物长期以来一直为传染病提供重要的药物先导。利什曼病是全球主要的健康问题，影响着数百万人，尤其是在发展中国家。目前尚无针对利什曼原虫感染的免疫预防措施（疫苗接种），传统治疗方法也不尽人意；因此，迫切需要抗利什曼原虫药物。在这项研究中，通过体外生物测定法对来自46种古巴植物的48种酒精提取物进行了抗亚马逊利什曼原虫的评估。此外，还测定了它们对小鼠巨噬细胞的毒性。对亚马逊利什曼原虫无鞭毛体阶段最有效的三种提取物分别来自响盒子、簕竹和苦木。
