古巴植物提取物对亚马逊利什曼原虫的活性。
Activity of Cuban Plants Extracts against Leishmania amazonensis.
作者信息
García Marley, Monzote Lianet, Scull Ramón, Herrera Pedro
机构信息
Department of Parasitology, Institute of Tropical Medicine "Pedro Kourí," Apdo Postal No. 601, Havana 10400, Cuba.
出版信息
ISRN Pharmacol. 2012;2012:104540. doi: 10.5402/2012/104540. Epub 2012 Mar 15.
Abstract
Natural products have long been providing important drug leads for infectious diseases. Leishmaniasis is a major health problem worldwide that affects millions of people especially in the developing nations. There is no immunoprophylaxis (vaccination) available for Leishmania infections, and conventional treatments are unsatisfactory; therefore, antileishmanial drugs are urgently needed. In this work, 48 alcoholic extracts from 46 Cuban plants were evaluated by an in vitro bioassay against Leishmania amazonensis. Furthermore, their toxicity was assayed against murine macrophage. The three most potent extracts against the amastigote stage of Leishmania amazonensis were from Hura crepitans, Bambusa vulgaris, and Simarouba glauca.
摘要
天然产物长期以来一直为传染病提供重要的药物先导。利什曼病是全球主要的健康问题，影响着数百万人，尤其是在发展中国家。目前尚无针对利什曼原虫感染的免疫预防措施（疫苗接种），传统治疗方法也不尽人意；因此，迫切需要抗利什曼原虫药物。在这项研究中，通过体外生物测定法对来自46种古巴植物的48种酒精提取物进行了抗亚马逊利什曼原虫的评估。此外，还测定了它们对小鼠巨噬细胞的毒性。对亚马逊利什曼原虫无鞭毛体阶段最有效的三种提取物分别来自响盒子、簕竹和苦木。
相似文献
1
Activity of Cuban Plants Extracts against Leishmania amazonensis.古巴植物提取物对亚马逊利什曼原虫的活性。
ISRN Pharmacol. 2012;2012:104540. doi: 10.5402/2012/104540. Epub 2012 Mar 15.
2
Screening of medicinal plants against Leishmania amazonensis.抗亚马逊利什曼原虫药用植物的筛选。
Pharm Biol. 2010 Sep;48(9):1053-8. doi: 10.3109/13880200903485729.
3
Antileishmanial activity of a naphthoquinone derivate against promastigote and amastigote stages of Leishmania infantum and Leishmania amazonensis and its mechanism of action against L. amazonensis species.一种萘醌衍生物对婴儿利什曼原虫和亚马逊利什曼原虫前鞭毛体和无鞭毛体阶段的抗利什曼活性及其对亚马逊利什曼原虫物种的作用机制。
Parasitol Res. 2018 Feb;117(2):391-403. doi: 10.1007/s00436-017-5713-6. Epub 2017 Dec 16.
4
Efficacy of vaccination with a combination of Leishmania amastigote antigens and the lipid A-analogue ONO-4007 for immunoprophylaxis and immunotherapy against Leishmania amazonensis infection in a murine model of New World cutaneous leishmaniasis.在新世界皮肤利什曼病的小鼠模型中，利什曼原虫无鞭毛体抗原与脂多糖类似物ONO - 4007联合疫苗接种对亚马逊利什曼原虫感染进行免疫预防和免疫治疗的效果。
Vaccine. 2006 Jul 7;24(27-28):5645-52. doi: 10.1016/j.vaccine.2006.03.023. Epub 2006 Mar 29.
5
Brazilian flora extracts as source of novel antileishmanial and antifungal compounds.巴西植物提取物作为新型抗利什曼原虫和抗真菌化合物的来源。
Mem Inst Oswaldo Cruz. 2008 Aug;103(5):443-9. doi: 10.1590/s0074-02762008000500006.
6
In Vitro Effects of the Neolignan 2,3-Dihydrobenzofuran Against Leishmania Amazonensis.新木脂素2,3-二氢苯并呋喃对亚马逊利什曼原虫的体外作用
Basic Clin Pharmacol Toxicol. 2017 Jan;120(1):52-58. doi: 10.1111/bcpt.12639. Epub 2016 Sep 16.
7
Leishmanicidal activity of Piper marginatum Jacq. from Santarém-PA against Leishmania amazonensis.来自帕拉州圣塔伦的 Piper marginatum Jacq. 对亚马逊利什曼原虫的杀利什曼原虫活性。
Exp Parasitol. 2020 Mar;210:107847. doi: 10.1016/j.exppara.2020.107847. Epub 2020 Jan 28.
8
The effect of the phytol-rich fraction from Lacistema pubescens against Leishmania amazonensis is mediated by mitochondrial dysfunction.来自柔毛拉西斯藤的富含叶绿醇部分对亚马逊利什曼原虫的作用是由线粒体功能障碍介导的。
Exp Parasitol. 2015 Dec;159:143-50. doi: 10.1016/j.exppara.2015.09.009. Epub 2015 Sep 28.
9
Antileishmanial activity of crude extract and coumarin from Calophyllum brasiliense leaves against Leishmania amazonensis.巴西红厚壳树叶粗提物及香豆素对亚马逊利什曼原虫的抗利什曼活性。
Parasitol Res. 2007 Aug;101(3):715-22. doi: 10.1007/s00436-007-0542-7. Epub 2007 May 5.
10
In vitro antileishmanial activity and cytotoxicity of essential oil from Lippia sidoides Cham.臭草（Lippia sidoides Cham.）精油的体外抗利什曼原虫活性及细胞毒性
Parasitol Int. 2011 Sep;60(3):237-41. doi: 10.1016/j.parint.2011.03.004. Epub 2011 Mar 21.
引用本文的文献
1
Bioassay-guided isolation of leishmanicidal cucurbitacins from .从……中进行生物测定引导的抗利什曼原虫葫芦素的分离。 （你提供的原文似乎不完整，最后的“from”后面缺少具体内容）
Front Pharmacol. 2024 Jul 11;15:1390715. doi: 10.3389/fphar.2024.1390715. eCollection 2024.
2
The therapeutic effect of larval saliva and hemolymph of Lucilia sericata on the treatment of Leishmania major lesion in BALB/c mice946.丝光绿蝇幼虫唾液和血液对治疗 BALB/c 小鼠大内脏利什曼原虫病变的疗效946.
Parasit Vectors. 2023 Feb 16;16(1):72. doi: 10.1186/s13071-023-05660-0.
3
Essential Oil from : Antimicrobial, Antikinetoplastid, Antiproliferative and Cytotoxic Assessment.来自：抗菌、抗原生动物、抗增殖和细胞毒性评估的精油。
Molecules. 2020 Nov 25;25(23):5514. doi: 10.3390/molecules25235514.
4
Chemical Constituents with Leishmanicidal Activity from a Pink-Yellow Cultivar of var. (L.) Collected in Central Mexico.墨西哥中部地区所产粉色-黄色栽培型 var. (L.) 的杀利什曼原虫活性化学成分研究。
Int J Mol Sci. 2019 Feb 18;20(4):872. doi: 10.3390/ijms20040872.
5
Antiparasitic activity in Asteraceae with special attention to ethnobotanical use by the tribes of Odisha, India.菊科植物的抗寄生虫活性，特别关注印度奥里萨邦部落的民族植物学用途。
Parasite. 2018;25:10. doi: 10.1051/parasite/2018008. Epub 2018 Mar 12.
6
The Anti-leishmanial Efficacy of Ethanolic Extract in Vitro and Its Effects on IFN-γ and IL-4 Response.乙醇提取物的体外抗利什曼原虫功效及其对IFN-γ和IL-4反应的影响。
Iran J Parasitol. 2017 Jul-Sep;12(3):398-407.
7
antileishmanial activity of Mexican medicinal plants.墨西哥药用植物的抗利什曼原虫活性
Heliyon. 2017 Sep 8;3(9):e00394. doi: 10.1016/j.heliyon.2017.e00394. eCollection 2017 Sep.
8
Photodynamic Therapy With Bengal Rose and Derivatives Against .孟加拉玫瑰及其衍生物的光动力疗法对抗……
J Lasers Med Sci. 2017 Winter;8(1):46-50. doi: 10.15171/jlms.2017.09. Epub 2017 Jan 8.
9
AND ANTILEISHMANIAL EFFECTS OF METHANOLIC EXTRACT FROM BARK OF APTERA.来自阿普特拉树皮的甲醇提取物的抗利什曼原虫作用
Afr J Tradit Complement Altern Med. 2017 Jan 13;14(2):188-197. doi: 10.21010/ajtcam.v14i2.20. eCollection 2017.
10
Plant-derived compounds in treatment of leishmaniasis.植物源化合物在利什曼病治疗中的应用
Iran J Vet Res. 2015 Winter;16(1):1-19.
本文引用的文献
1
In vitro antimalarial activity and cytotoxicity of some selected cuban medicinal plants.某些选定古巴药用植物的体外抗疟活性和细胞毒性
Rev Inst Med Trop Sao Paulo. 2010 Jul-Aug;52(4):197-201. doi: 10.1590/s0036-46652010000400006.
2
Screening of medicinal plants against Leishmania amazonensis.抗亚马逊利什曼原虫药用植物的筛选。
Pharm Biol. 2010 Sep;48(9):1053-8. doi: 10.3109/13880200903485729.
3
Metabolomics for bioactivity assessment of natural products.代谢组学在天然产物生物活性评估中的应用。
Phytother Res. 2011 Feb;25(2):157-69. doi: 10.1002/ptr.3258.
4
Chemistry, cytotoxicity and antileishmanial activity of the essential oil from Piper auritum.Piper auritum 精油的化学成分、细胞毒性和抗利什曼原虫活性。
Mem Inst Oswaldo Cruz. 2010 Mar;105(2):168-73. doi: 10.1590/s0074-02762010000200010.
5
Momordicatin purified from fruits of Momordica charantia is effective to act as a potent antileishmania agent.从苦瓜果实中纯化得到的苦瓜素可有效作为一种强力抗利什曼原虫剂。
Parasitol Int. 2010 Jun;59(2):192-7. doi: 10.1016/j.parint.2010.01.004. Epub 2010 Feb 1.
6
In vitro activities of plant extracts from Saudi Arabia against malaria, leishmaniasis, sleeping sickness and Chagas disease.沙特阿拉伯植物提取物抗疟疾、利什曼病、昏睡病和恰加斯病的体外活性。
Phytother Res. 2010 Sep;24(9):1322-8. doi: 10.1002/ptr.3108.
7
Assessment of anti-protozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis.评估厄瓜多尔传统用于治疗利什曼病的植物的抗原生动物活性。
J Ethnopharmacol. 2010 Mar 2;128(1):184-97. doi: 10.1016/j.jep.2010.01.007. Epub 2010 Jan 11.
8
Abortifacient potentials of the aqueous extract of Bambusa vulgaris leaves in pregnant Dutch rabbits.Bambusa vulgaris 叶水提取物对怀孕荷兰兔的堕胎潜力
Contraception. 2009 Sep;80(3):308-13. doi: 10.1016/j.contraception.2009.03.003. Epub 2009 Apr 22.
9
Medicinal plants from the Yanesha (Peru): evaluation of the leishmanicidal and antimalarial activity of selected extracts.来自亚内沙人（秘鲁）的药用植物：所选提取物的杀利什曼原虫和抗疟活性评估
J Ethnopharmacol. 2009 Jun 25;123(3):413-22. doi: 10.1016/j.jep.2009.03.041.
10
Antileishmanial activity in Israeli plants.以色列植物的抗利什曼原虫活性。
Ann Trop Med Parasitol. 2009 Jun;103(4):297-306. doi: 10.1179/136485909X440827.
Zotero 插件