Department of Oral Medicine, Islamic Azad University, Dental Branch, Tehran, Iran.
J Oral Pathol Med. 2012 Aug;41(7):524-6. doi: 10.1111/j.1600-0714.2012.01138.x. Epub 2012 Apr 24.
Oral lichen planus (OLP) is a chronic, mucocutaneous, inflammatory disease. It has become more evident that the immune system plays a primary role in the development of this disease. The aim of the present study was to evaluate the total antioxidant status (TAS) of saliva and serum in patients with erosive OLP.
This study was designed as case-control. In total, 48 patients with erosive OLP (34 women and 14 men) were enrolled as case group, and 44 self-admitted healthy people (34 women and 10 men) were selected as control group. Measurement of total antioxidant status was carried out in saliva and plasma. t-test was used for statistical analysis with significant level set at P < 0.05.
The mean ± SD of salivary TAS in case group was 0.98 ± 0.12, and in control group was 1.32 ± 0.18 mM, respectively, and there were significant differences between groups (P < 0.02). The mean ± SD of the plasma TAS in the case group and the control group was 1.24 ± 0.17 and 1.84 ± 0.34 mM, respectively. There were significant differences between two groups (P < 0.01).
Our results showed that salivary and plasma levels of total antioxidant status in erosive OLP patients were lower than those in healthy subjects.
口腔扁平苔藓（OLP）是一种慢性、黏膜皮肤、炎症性疾病。免疫系统在这种疾病的发展中起着主要作用，这一点变得越来越明显。本研究旨在评估糜烂性 OLP 患者唾液和血清中的总抗氧化状态（TAS）。
本研究设计为病例对照研究。共纳入 48 例糜烂性 OLP 患者（34 名女性和 14 名男性）作为病例组，44 名自我承认的健康人（34 名女性和 10 名男性）作为对照组。在唾液和血浆中测量总抗氧化状态。采用 t 检验进行统计分析，显著水平设为 P < 0.05。
病例组唾液 TAS 的平均值±标准差为 0.98±0.12，对照组为 1.32±0.18 mM，两组间差异有统计学意义（P < 0.02）。病例组和对照组血浆 TAS 的平均值±标准差分别为 1.24±0.17 和 1.84±0.34 mM，两组间差异有统计学意义（P < 0.01）。
我们的结果表明，糜烂性 OLP 患者唾液和血浆中的总抗氧化状态水平低于健康受试者。
