人乳头瘤病毒 120 型的特征：一种具有多种解剖部位趋向性的新型β乳头瘤病毒。
Characterization of human papillomavirus type 120: a novel betapapillomavirus with tropism for multiple anatomical niches.
机构信息
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1105 Ljubljana, Slovenia.
出版信息
J Gen Virol. 2012 Aug;93(Pt 8):1774-1779. doi: 10.1099/vir.0.041897-0. Epub 2012 May 2.
Abstract
Recent studies indicate that human papillomaviruses (HPVs) from the genera Betapapillomavirus and Gammapapillomavirus are abundant in the human oral cavity. We report the cloning and characterization of a 7304 bp HPV120 genome from the oral cavity that is related most closely to HPV23 (L1 ORF, 83.7 % similarity), clustering it in the genus Betapapillomavirus (β-PV). HPV120 contains five early and two late genes, but no E5 ORF. HPV120 was detected from heterogeneous human biological niches, including the oral cavity, eyebrow hairs, anal canal and penile, vulvar and perianal warts. Characterization of the clinical spectrum of HPV120 infections indicates a broader spectrum of epithelial tropism than appreciated previously for HPV types from the genus β-PV.
摘要
最近的研究表明，β属和 γ属乳头瘤病毒（HPV）在人类口腔中大量存在。我们报道了从口腔中克隆和鉴定出的一种 7304 碱基对的 HPV120 基因组，它与 HPV23 最为密切相关（L1 ORF，83.7%相似性），将其归类为 β 属乳头瘤病毒（β-PV）。HPV120 包含五个早期基因和两个晚期基因，但没有 E5 ORF。HPV120 存在于口腔、眉毛、肛门和阴茎、外阴和肛周疣等多种人体生物腔隙中。对 HPV120 感染临床谱的特征分析表明，与之前认为的 β-PV 属 HPV 类型相比，HPV120 具有更广泛的上皮嗜性。
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