Grice Elizabeth A, Kong Heidi H, Conlan Sean, Deming Clayton B, Davis Joie, Young Alice C, Bouffard Gerard G, Blakesley Robert W, Murray Patrick R, Green Eric D, Turner Maria L, Segre Julia A
Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA.
Science. 2009 May 29;324(5931):1190-2. doi: 10.1126/science.1171700.
Human skin is a large, heterogeneous organ that protects the body from pathogens while sustaining microorganisms that influence human health and disease. Our analysis of 16S ribosomal RNA gene sequences obtained from 20 distinct skin sites of healthy humans revealed that physiologically comparable sites harbor similar bacterial communities. The complexity and stability of the microbial community are dependent on the specific characteristics of the skin site. This topographical and temporal survey provides a baseline for studies that examine the role of bacterial communities in disease states and the microbial interdependencies required to maintain healthy skin.
人类皮肤是一个庞大的、异质性的器官，它在保护身体免受病原体侵害的同时，维持着影响人类健康和疾病的微生物群落。我们对从健康人的20个不同皮肤部位获得的16S核糖体RNA基因序列进行分析后发现，生理上具有可比性的部位拥有相似的细菌群落。微生物群落的复杂性和稳定性取决于皮肤部位的特定特征。这项地形学和时间性的调查为研究细菌群落在疾病状态中的作用以及维持健康皮肤所需的微生物相互依存关系提供了一个基线。
