The Laboratory of Cell and Molecular Biology, NIDDK, NIH, Bethesda, Maryland 20892, USA.
J Cell Biochem. 2012 Sep;113(9):2813-21. doi: 10.1002/jcb.24178.
Take a look at a textbook illustration of a cell and you will immediately be able to locate the nucleus, which is often drawn as a spherical or ovoid shaped structure. But not all cells have such nuclei. In fact, some disease states are diagnosed by the presence of nuclei that have an abnormal shape or size. What defines nuclear shape and nuclear size, and how does nuclear geometry affect nuclear function? While the answer to the latter question remains largely unknown, significant progress has been made towards understanding the former. In this review, we provide an overview of the factors and forces that affect nuclear shape and size, discuss the relationship between ER structure and nuclear morphology, and speculate on the possible connection between nuclear size and its shape. We also note the many interesting questions that remain to be explored.
看一下细胞的教科书插图，你会立即找到细胞核，它通常被画成球形或椭圆形的结构。但并非所有细胞都有这样的细胞核。事实上，一些疾病状态是通过具有异常形状或大小的细胞核来诊断的。是什么定义了核的形状和大小，以及核的几何形状如何影响核的功能？虽然后者的答案在很大程度上仍然未知，但在理解前者方面已经取得了重大进展。在这篇综述中，我们概述了影响核形状和大小的因素和力，讨论了内质网结构与核形态之间的关系，并推测了核大小与其形状之间可能存在的联系。我们还注意到仍有许多有趣的问题有待探索。
