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采用芯片级原子磁力仪的脑磁图技术。

Magnetoencephalography with a chip-scale atomic magnetometer.

作者信息

Sander T H, Preusser J, Mhaskar R, Kitching J, Trahms L, Knappe S

出版信息

Biomed Opt Express. 2012 May 1;3(5):981-90. doi: 10.1364/BOE.3.000981. Epub 2012 Apr 17.

DOI:10.1364/BOE.3.000981
PMID:22567591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3342203/
Abstract

We report on the measurement of somatosensory-evoked and spontaneous magnetoencephalography (MEG) signals with a chip-scale atomic magnetometer (CSAM) based on optical spectroscopy of alkali atoms. The uncooled, fiber-coupled CSAM has a sensitive volume of 0.77 mm(3) inside a sensor head of volume 1 cm(3) and enabled convenient handling, similar to an electroencephalography (EEG) electrode. When positioned over O1 of a healthy human subject, α-oscillations were observed in the component of the magnetic field perpendicular to the scalp surface. Furthermore, by stimulation at the right wrist of the subject, somatosensory-evoked fields were measured with the sensors placed over C3. Higher noise levels of the CSAM were partly compensated by higher signal amplitudes due to the shorter distance between CSAM and scalp.

摘要

我们报告了基于碱金属原子光谱学的芯片级原子磁力计(CSAM)对体感诱发电位和自发脑磁图(MEG)信号的测量。这种未冷却的、光纤耦合的CSAM在体积为1立方厘米的传感器头内部具有0.77立方毫米的灵敏体积,并且便于操作,类似于脑电图(EEG)电极。当放置在健康人类受试者的O1位置上方时,在垂直于头皮表面的磁场分量中观察到了α振荡。此外,通过刺激受试者的右手腕,使用放置在C3上方的传感器测量了体感诱发电场。由于CSAM与头皮之间的距离较短,较高的信号幅度部分补偿了CSAM较高的噪声水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddda/3342203/067107614017/boe-3-5-981-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddda/3342203/f0c6a8ac5c83/boe-3-5-981-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddda/3342203/0eb2982cefe1/boe-3-5-981-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddda/3342203/ba54d935652a/boe-3-5-981-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddda/3342203/a19977262a30/boe-3-5-981-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddda/3342203/8fa8d2731d7a/boe-3-5-981-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddda/3342203/067107614017/boe-3-5-981-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddda/3342203/f0c6a8ac5c83/boe-3-5-981-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddda/3342203/0eb2982cefe1/boe-3-5-981-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddda/3342203/ba54d935652a/boe-3-5-981-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddda/3342203/a19977262a30/boe-3-5-981-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddda/3342203/8fa8d2731d7a/boe-3-5-981-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddda/3342203/067107614017/boe-3-5-981-g006.jpg

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