NAICONS, Via G. Fantoli 16/15, 20138, Milan, Italy.
J Nat Prod. 2012 Jun 22;75(6):1044-50. doi: 10.1021/np300003n. Epub 2012 May 22.
Two new members of the spirotetronate class, nai414-A and nai414-B, were discovered and isolated from an Actinoallomurus sp. Their structures were established by 1D and 2D NMR, UV, and MS analyses and by chemical degradation. They showed antimicrobial and antitumor activity against Gram-positive bacteria and against human microvascular endothelial cells, respectively. Substituting bromide for chloride ions in the growth medium afforded mono- and dibrominated derivatives.
从一株游动放线菌中发现并分离得到两个新的螺缩酮类化合物，nai414-A 和 nai414-B。其结构通过 1D 和 2D NMR、UV 和 MS 分析以及化学降解等方法确定。它们对革兰氏阳性菌具有抗菌活性，对人微血管内皮细胞具有抗肿瘤活性。在培养基中用溴化物取代氯离子可以得到单溴代和二溴代衍生物。
