Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Suedufer 10, D-17493 Greifswald-Insel Riems, Germany.
Institute of Infectology, Friedrich-Loeffler-Institut, Suedufer 10, D-17493 Greifswald-Insel Riems, Germany.
J Gen Virol. 2012 Aug;93(Pt 8):1658-1663. doi: 10.1099/vir.0.042648-0. Epub 2012 May 23.
The incursion of the human pandemic influenza A virus H1N1 (2009) (H1N1 pdm) into pig populations and its ongoing co-circulation with endemic swine influenza viruses (SIVs) has yielded distinct human-porcine reassortant virus lineages. The haemagglutinin (HA) gene of H1N1 pdm was detected in 41 influenza virus-positive samples from seven swine herds in north-west Germany in 2011. Eight of these samples yielded virus that carried SIV-derived neuraminidase N2 of three different porcine lineages in an H1N1 pdm backbone. The HA sequences of these viruses clustered in two distinct groups and were distinguishable from human and other porcine H1 pdm by a unique set of eight non-synonymous mutations. In contrast to the human population, where H1N1 pdm replaced seasonal H1N1, this virus seems to co-circulate and interact more intensely with endemic SIV lineages, giving rise to reassortants with as-yet-unknown biological properties and undetermined risks for public health.
人感染甲型流感 H1N1 病毒（2009 年）（H1N1 pdm）入侵猪群，并与地方性猪流感病毒（SIV）持续共同循环，产生了独特的人-猪重组病毒谱系。2011 年，在德国西北部的七个养猪场的 41 份流感病毒阳性样本中检测到 H1N1 pdm 的血凝素（HA）基因。其中 8 个样本产生的病毒在 H1N1 pdm 骨架中携带了源自三种不同猪谱系的 SIV 衍生的神经氨酸酶 N2。这些病毒的 HA 序列聚类为两个不同的组，通过一组独特的八个非同义突变与人和其他猪 H1 pdm 区分开来。与人类中 H1N1 pdm 取代季节性 H1N1 的情况不同，这种病毒似乎与地方性 SIV 谱系更频繁地共同循环和相互作用，产生具有未知生物学特性和对公共卫生不确定风险的重组病毒。
