Department of Molecular Genetics, Medical Institute of Bioregulation, Fukuoka, Japan.
Adv Exp Med Biol. 2012;746:2-11. doi: 10.1007/978-1-4614-3146-6_1.
Glioblastoma (GBM) is the most aggressive form of glioma. Despite ceaseless efforts by researchers and physicians to find new therapeutic strategies, there have been no significant advances in the treatment of GBMs for several decades and most patients with GBM die within one and half years of diagnosis. Undoubtedly, one reason for this is the insufficient understanding of the initiation and progression of GBMs at the molecular level. However, recent information regarding the genetic and epigenetic alterations and the microRNAs that are aberrantly activated or inactivated in GBMs has helped elucidate the formation of GBM in more detail. Here, we describe recent advances in the understanding of the biology of GBMs.
胶质母细胞瘤（GBM）是最具侵袭性的神经胶质瘤。尽管研究人员和医生不断努力寻找新的治疗策略，但几十年来，GBM 的治疗并没有取得重大进展，大多数 GBM 患者在诊断后一年内半内死亡。毫无疑问，造成这种情况的原因之一是对 GBM 在分子水平上的发生和发展的认识不足。然而，最近关于 GBM 中遗传和表观遗传改变以及异常激活或失活的 microRNAs 的信息，有助于更详细地阐明 GBM 的形成。在这里，我们描述了对 GBM 生物学的理解的最新进展。
