mTOR 信号转导的发现
Found in translation of mTOR signaling.
机构信息
Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
出版信息
Cell Res. 2012 Sep;22(9):1315-8. doi: 10.1038/cr.2012.85. Epub 2012 May 29.
Abstract
The mammalian target of rapamycin (mTOR) protein kinase regulates a wide variety of cellular processes, including protein synthesis, yet the downstream translational program under the control of mTOR is poorly understood. Two recent studies by Hsieh et al. and Thoreen et al. now start to address this issue, and uncover a subset of genes translationally regulated by oncogenic mTOR signaling that may contribute to tumorigenesis.
摘要
哺乳动物雷帕霉素靶蛋白（mTOR）激酶调节着广泛的细胞过程，包括蛋白质合成，但目前对 mTOR 控制下的下游翻译程序知之甚少。Hsieh 等人和 Thoreen 等人最近的两项研究开始解决这个问题，并揭示了一组受致癌性 mTOR 信号转导翻译调控的基因，这些基因可能有助于肿瘤发生。
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本文引用的文献
1
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Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083.
2
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Nature. 2012 Feb 22;485(7396):55-61. doi: 10.1038/nature10912.
3
High-resolution view of the yeast meiotic program revealed by ribosome profiling.高分辨率观察酵母减数分裂程序揭示了核糖体图谱。
Science. 2012 Feb 3;335(6068):552-7. doi: 10.1126/science.1215110. Epub 2011 Dec 22.
4
Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes.鼠胚胎干细胞的核糖体图谱分析揭示了哺乳动物蛋白质组的复杂性和动态性。
Cell. 2011 Nov 11;147(4):789-802. doi: 10.1016/j.cell.2011.10.002. Epub 2011 Nov 3.
5
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6
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