Bowe Whitney P, Patel Nayan, Logan Alan C
SUNY Downstate Medical Center, Department of Dermatolgy, Brooklyn, NY, USA.
J Drugs Dermatol. 2012 Jun;11(6):742-6.
Acne vulgaris is a common dermatological condition characterized by hormonally-mediated sebum overproduction, follicular hyperkeratinization, and chronic inflammation of the pilosebaceous unit. Microbes, genetic susceptibilities, and various environmental factors have been linked to the pathogenesis of the condition. Over the last several years it has become apparent that patients with acne are under increased cutaneous and systemic oxidative stress. Moreover, the burden of oxidative stress may not be a mere consequence of acne; rather, the oxidative stress, lipid peroxidation in particular, may be an early event that helps to drive the acne process. Here, we explore the role of oxidative stress and review the preliminary research involving the administration of local and systemic antioxidants.
寻常痤疮是一种常见的皮肤病，其特征是由激素介导的皮脂过度分泌、毛囊过度角化以及皮脂腺单位的慢性炎症。微生物、遗传易感性和各种环境因素都与该病的发病机制有关。在过去几年中，很明显痤疮患者存在皮肤和全身氧化应激增加的情况。此外，氧化应激负担可能不仅仅是痤疮的结果；相反，氧化应激，尤其是脂质过氧化，可能是促使痤疮发病的早期事件。在此，我们探讨氧化应激的作用，并综述有关局部和全身使用抗氧化剂的初步研究。
