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比较 PapType 与 Digene Hybrid Capture 2、罗氏线性阵列和 Amplicor 检测既往巴氏涂片异常女性的高危型人乳头瘤病毒基因型。

Comparison of PapType to Digene Hybrid Capture 2, Roche linear array, and Amplicor for detection of high-risk human papillomavirus genotypes in women with previous abnormal pap smears.

机构信息

Regional WHO HPV Reference Laboratory, Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia.

出版信息

J Clin Microbiol. 2012 Aug;50(8):2796-8. doi: 10.1128/JCM.01064-12. Epub 2012 May 30.

DOI:10.1128/JCM.01064-12
PMID:22649012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3421518/
Abstract

PapType human papillomavirus (HPV) assay was compared to Hybrid Capture 2 (HC2), Amplicor (Amp), and Linear Array (LA) HPV tests in 894 women undergoing management for a high-grade Pap smear abnormality. The sensitivity in detection of underlying high-grade histological diagnosis by PapType was 90.3% and by HC2 was 79.8%, while by Amp and LA it was 92.4% and 91.6%, respectively. The specificities were 52.5%, 55.3%, 49.4%, and 51.7% for PapType, HC2, Amp, and LA, respectively.

摘要

在对 894 名因巴氏涂片异常而接受高级别巴氏涂片异常管理的女性进行的一项研究中，比较了 PapType 人乳头瘤病毒（HPV）检测与 Hybrid Capture 2（HC2）、Amplicor（Amp）和 Linear Array（LA）HPV 检测。PapType 检测对潜在高级别组织学诊断的敏感性为 90.3%，HC2 为 79.8%，Amp 和 LA 分别为 92.4%和 91.6%。PapType、HC2、Amp 和 LA 的特异性分别为 52.5%、55.3%、49.4%和 51.7%。

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